Publications
Dürre P., Eikmanns B.J. (2015) C1-carbon sources for chemical and fuel production by microbial gas fermentation. Review. Curr Opin Biotechnol. 35:63-72 PubMed
Clermont L., Macha A., Müller L.M., Derya S.M., von Zaluskowski P., Eck A., Eikmanns B.J., Seibold G.M. (2015) The α-glucan phosphorylase MalP of Corynebacterium glutamicum is subject to transcriptional regulation and competitive inhibition by ADP-glucose. J Bacteriol. 197(8):1394-407 PubMed
Eikmanns B.J. & Blombach B. (2014a) The pyruvate dehydrogenase complex of Corynebacterium glutamicum: an attractive target for metabolic engineering. J. Biotechnol. 192:339-345 PubMed
Eikmanns B.J. & Blombach B. (2014b) Isobutanol. In: Bioprocessing of renewable resources to commodity bioproducts. V.S. Bisaria & A. Kondo (Eds.), John Wiley and Sons, Inc., pp. 327-352, ISBN: 978-1-118-17583-5
Radoš D., Turner D.L., Fonseca L., Carvalho A.L., Blombach B., Eikmanns B., Neves A.R. & Santos H. (2014) The effect of CO2 on anaerobic succinate production by Corynebacterium glutamicum. carbon flux analysis by 13C-NMR. Appl. Environ. Microbiol. 80:3015-3024 PubMed
Oldiges M., Eikmanns B.J. & Blombach B. (2014) Application of metabolic engineering for the biotechnological production of L-valine. Appl. Microbiol. Biotechnol. 98:5859-5870 PubMed
Blombach B. & Eikmanns B.J. (2014c) Maßgeschneiderte Zellfabriken - Corynebacterium glutamicum als Produzent von Pyruvat-abgeleiteten Produkten. BIOspektrum 06.14:696-699
Bückle-Vallant V., Krause F., Messerschmidt S. & Eikmanns B.J. (2014) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisocaproate production. Appl. Microbiol. Biotechnol. 98:297-311 PubMed
Wieschalka S., Blombach B., Bott M. & Eikmanns B.J. (2013) Bio-based production of organic acids with Corynebacterium glutamicum. Microb. Biotechnol. 6:87-102 PubMed
Lindner S.N., Petrov D.P., Hagmann C.T., Henrich A., Krämer R., Eikmanns B.J., Wendisch V.F. & Seibold G.M. (2013) Phosphotransferase system- (PTS-) mediated glucose uptake is repressed in phosphoglucoisomerase-deficient Corynebacterium glutamicum strains. Appl. Environ. Microbiol. 79:2588-2595 PubMed
Klaffl S., Brocker M., Kalinowski J., Eikmanns B.J. & Bott M. (2013) Complex regulation of the PEP carboxykinase gene pck and characterization of ist GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum. J. Bacteriol. 195:4283-4296 PubMed
Seibold G. & Eikmanns B.J. (2013) Inactivation of the phosphoglucomutase gene pgm in Corynebacterium glutamicum affects cell shape development and glycogen metabolism. Biosci. Rep. 33 (4), art:e00059 PubMed
Buchholz J., Schwentner A., Brunnenkan B., Gabris C., Grimm S., Gerstmeir R., Takors R., Eikmanns B.J. & Blombach B. (2013) Platform engineering: Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improveed production of L-lysine, L-valine, 2-ketoisovalerate. Appl. Environ. Microbiol. 19:5566-5575 PubMed
Bott M. & Eikmanns B.J. (2012) TCA cycle and glyoxylate shunt of Corynebacterium glutamicum. In: Corynebacterium glutamicum: Biology and Biotechnology (Microbiology Monographs), Yukawa H. & Inui M. (eds), Springer Verlag Berlin Heidelberg, pp. 281-314
Laslo T., von Zaluskowski P., Gabris C., Lodd E., Rückert C., Dangel P., Kalinowski J., Auchter M., Seibold G., Eikmanns B. J. (2012) Arabitol metabolism of Corynebacterium glutamicum and its regulation by AtlR. J. Bacteriol. 194:941-55. PubMed
Wieschalka S., Blombach B., Eikmanns B. J. (2012) Engineering Corynebacterium glutamicum for the production of pyruvate. Appl. Microbiol. Biotechnol. 94:449-59. PubMed
Blombach B. & Eikmanns B.J. (2011) Current knowledge on isobutanol production with Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum. Bioeng. Bugs 2(6):346-50 PubMed
Seibold G.M., Breitinger K.J., Kempkes R., Both L., Krämer M., Dempf S. & Eikmanns B.J. (2011) The glgB encoded glycogen branching enzyme is essential for glycogen accumulation in Corynebacterium glutamicum. Microbiology 157:3243-51 PubMed
Bartek T., Blombach B., Lang S., Eikmanns B.J., Oldiges M., Nöh K. & Noack S. (2011) Comparative 13C-metabolic flux analysis of PDHC-deficient L-valine producting Corynebacterium glutamicum. Appl. Environ. Microbiol. 77:6644-6652 PubMed
Auchter M., Laslo T., Fleischer C., Schiller L., Arndt A., Gaigalat L., Kalinowski J. & Eikmanns B.J. (2011) Control of adhA and sucR expression by the SucR regulator in Corynebacterium glutamicum. J. Biotechnol. 152:77-86 PubMed
van der Ooyen J., Emer D., Bussmann M., Bott M., Eikmanns B.J. & Eggeling L. (2011) Citrate synthase in Corynebacterium glutamicum is encoded by two gltA transcripts, which are controlled by RamA, RamB and GlxR. J. Biotechnol. 154:140-148 PubMed
Auchter M., Cramer A., Hüser A., Rückert C., Emer D., Schwarz P., Arndt A., Lange C., Kalinowski J., Wendisch V.F. & Eikmanns B.J. (2011) RamA and RamB are global regulators in Corynebacterium glutamicum and control enzymes of the central metabolism. J. Biotechnol. 154:126-139 PubMed
Blombach B., Riester T., Wieschalka S., Ziert C., Youn J.-W., Wendisch V.F. & Eikmanns B.J. (2011) Corynebacterium glutamicum tailored for efficient isobutanol production. Appl. Environ. Microbiol. 77:3300-10 PubMed
Krause F.S., Blombach B., Eikmanns B.J. (2010) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl Environ Microbiol. 76(24):8053-61. PubMed
Woo H.M., Noack S.,Seibold G., Willbold S., Eikmanns B.J. & Bott M. (2010) A link between phosphate starvation and glycogen metabolism in Corynebacterium glutamicum revealed by metabolomics. Appl. Environ. Microbiol. 76:6910-6919. PubMed
Seibold G.M., Hagmann C., Schietzel M., Emer D., Auchter M., Schreiner J. & Eikmanns B.J. (2010) The transcriptional regulators RamA and RamB are involved in the regulation of glycogen synthesis in Corynebacterium glutamicum. Microbiology 156:1256-1263.PubMed
Krause F.S., Henrich A., Blombach B., Krämer R., Eikmanns B. J. & Seibold G. M. (2010) Increased glucose utilization in Corynebacterium glutamicum by use of maltose and its application for the improvement of L-valine productivity. Appl. Environ. Microbiol. 76:370-374. PubMed
Bartek T., Blombach B., Zönnchen E., Makus P., Lang S., Eikmanns B. J. & Oliges M. (2010) Importance of NADPH supply for improved L-valine formation in Corynebacterium glutamicum. Biotechnol. Prog. 26:361-371.PubMed
Bartek T., Rudolf C., Kerßen U., Klein B., Blombach B., Eikmanns B.J. & Oldiges M. (2010) Studies on substrate utilization in L-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex. Bioprocess Biosyst. Eng. 33:873-883.PubMed
Klaffl S. & Eikmanns B.J. (2010) Genetical and functional analysis of the soluble oxaloacetate decarboxylase from Corynebacterium glutamicum. J. Bacteriol. 192:2604-2612.PubMed
Micklinghoff J., Breitinger K., Schmidt M., Geffers R., Eikmanns B.J. & Bange F.C. (2009) The role of the transcriptional regulator RamB (Rv0465c) in control of the glyoxylate cycle in Mycobacterium tuberculosis. J. Bacteriol. 191:7260-7269. PubMed
Bussmann M., Emer D., Hasenbein S., Degraf S., Eikmanns B.J. & Bott M. (2009) Transcriptional control of the succinate dehydrogenase operon sdhCAB of Corynebacterium glutamicum by the cAMP-dependent regulator GlxR and the LuxR-type regulator RamA. J. Biotechnol. 143:173-182. PubMed
Blombach B., Arndt A., Auchter M. & Eikmanns B.J. (2009) L-Valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR. Appl. Environ. Microbiol. 75:1197-1200. PubMed
Seibold G.M., Wurst M. & Eikmanns B.J. (2009) Roles of maltodextrin and glycogen phosphorylases in maltose utilisation and glycogen metabolism in Corynebacterium glutamicum. Microbiology 155:347-358. PubMed
Blombach B., Hans S., Bathe B. & Eikmanns B.J. (2009) Acetohydroxyacid synthase: A novel target to improve L-lysine production with Corynebacterium glutamicum. Appl. Environ. Microbiol. 75:419-427. PubMed
Emer D., Krug A., Eikmanns B.J. & Bott M. (2009) Complex expression control of the Corynebacterium glutamicum aconitase gene: identification of RamA as a third transcriptional regulator besides AcnR and RipA. J. Biotechnol. 140:92-98. PubMed
Jolkver E., Ballan S., Emer D., Krämer R., Eikmanns B.J. & Marin K. (2009) Identification and characterization of a bacterial transport system for the uptake of pyruvate, propionate, and acetate in Corynebacterium glutamicum. J. Bacteriol. 191: 940-948. PubMed
Veit A., Rittmann D., Georgi T., Youn J.-W., Eikmanns B.J. & Wendisch V.F. (2009) Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum. J. Biotechnol. 140:75-83. PubMed
Auchter M., Arndt A. & Eikmanns B.J. (2009) Dual transcriptional control of acetaldehyde dehydrogenase gene ald of Corynebacterium glutamicum by RamA and RamB. J. Biotechnol. 140:84-91. PubMed
Blombach B., Cramer A., Eikmanns B.J. & Schreiner M. (2009) RamB is an activator of the E1p gene in Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 16:236-239. PubMed
Arndt A. & Eikmanns B.J. (2008). Regulation of carbon metabolism in Corynebacterium glutamicum. In: Corynebacteria: Genomics and Molecular Biology, Burkovski A. (ed), pp. 155-182, Horizon Scientific press, Norwich, UK www.horizonpress.com/cory
Blombach B., Schreiner M.E., Bartek T., Oldiges M. & Eikmanns B.J. (2008) Corynebacterium glutamicum tailored for high yield L-Valine production. Appl. Microbiol. Biotechnol. 79:471-479. PubMed
Arndt A., Auchter M., Ishige T., Wendisch V.F. & Eikmanns B.J. (2007) Ethanol catabolism in Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 15:222-233. PubMed
Seibold G.M. & Eikmanns B.J. (2007b) The glgX gene product of Corynebacterium glutamicum is required for glycogen degradation and for fast adaptation to hyperosmotic stress. Microbiology 153:2212-2220. PubMed
Seibold G., Dempf S., Schreiner J. & Eikmanns B.J. (2007a) Glycogen formation in Corynebacterium glutamicum and role of ADP-glucose pyrophosphorylase. Microbiology 153:1275-1285. PubMed
Blombach B., Schreiner M., Moch M., Oldiges M. & Eikmanns B.J. (2007) Effect of pyruvate dehydrogenase complex-deficiency on L-lysine production with Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 76:615-623. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17333167&query_hl=1&itool=pubmed_docsumPubMed
Arndt, A. & Eikmanns B.J. (2007) The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression. J. Bacteriol. 189:7408-7416. PubMed
Blombach B., Schreiner M.E., Holatko, J., Bartek T., Oldiges M. & Eikmanns B.J. (2007) L-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl. Environm. Microbiol. 73:2079-2084. PubMed
Cramer, A. & Eikmanns, B.J. (2007) RamA, the Transcriptional Regulator of Acetate Metabolism in Corynebacterium glutamicum, Is Subject to Negative Autoregulation. J Mol Microbiol Biotechnol. 12(1-2):51-59. PubMed
Cramer, A., Auchter, M., Frunzke, J. & Eikmanns, B.J. (2007) RamB, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum is subject to regulation by RamA and RamB. J Bacteriol. 189:1145-1149. PubMed
Wendisch V.F., Bott M. & Eikmanns B.J. (2006) Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids. Curr. Opin. Microbiol. 9:268-274. PubMed
Mansi M., Cozzone A.J., Shiloach J. & Eikmanns B.J. (2006) Control of carbon flux via enzymes of central and intermediary metabolism during growth of Escherichia coli on acetate. Curr. Opin. Microbiol. 9:173-179. PubMed
Cramer A., Gerstmeir R., Schaffer S., Bott M. & Eikmanns B.J. (2006) Identification of RamA, a novel LuxR-type transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum. J. Bacteriol. 188:2554-2567. PubMed
Seibold G., Auchter M., Berens S., Kalinowski J. & Eikmanns B.J. (2006) Utilization of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production. J. Biotechnol. 124:381-391. PubMed
Schreiner M.E., Riedel C., Holatko J., Patek M. & Eikmanns B.J. (2006) Pyruvate: Quinone Oxidoreductase from Corynebacterium glutamicum: Molecular Analysis of the pqo Gene, Significance of the Enzyme and Phylogenetic Aspects. J. Bacteriol. 188:1341-1350. PubMed
Schreiner M.E., Fiur D., Holatko J., Patek M. & Eikmanns B.J. (2005) E1 Enzyme of the Pyruvate Dehydrogenase Complex in Corynebacterium glutamicum: Molecular Analysis of the Gene and Phylogenetic Aspects. J. Bacteriol. 187:6005-6018. PubMed
Eikmanns B.J. (2005) Central metabolic pathways of Corynebacterium glutamicum: tricarboxylic cycle and anaplerotic reactions. In Handbook of Corynebacterium glutamicum, Eggeling, L. and Bott, M. (eds), pp. 241-276, CRC Press, Boca Raton, Florida, USA
Sauer U. & Eikmanns B.J. (2005) The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria. FEMS Microbiol. Rev. 29:765-794. PubMed
Schreiner M & Eikmanns B.J. (2005) Pyruvate: quinone oxidoreductase from Corynebacterium glutamicum: Purification and biochemical characterization. J. Bacteriol. 187:862-871. PubMed
Gerstmeir R., Cramer A., Dangel P., Schaffer S. & Eikmanns B.J. (2004) RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum. J. Bacteriol. 186:2798-2809. PubMed
Kalinowski J., Bathe B., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Krämer R., Linke B., McHardy A.C., Meyer F., Möckel B., Pfefferle W., Pühler A., Rey D., Rückert C., Rupp, O., Sahm H., Wendisch V.F., Wiegräbe I. & Tauch A. (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J. Biotechnol. 104:5-25. PubMed
Gerstmeir R., Wendisch V.F., Schnicke S., Ruan H., Farwick M., Reinscheid D. & Eikmanns B.J. (2003) Acetate metabolism and its regulation in Corynebacterium glutamicum. J. Biotechnol. 104:99-122. PubMed