PURA Syndrome is a genetically caused, rare neuro-developmental disorder. The Niessing lab, together with the group of Dr. Kathi Zarnack (Frankfurt University) and the Helmholtz Zentrum München investigated what happens on a cellular level in this disorder. Both teams have now come a significant step closer to solving the mystery. The study showed that not only the immune responses and the "garbage disposal" of the cells were affected, but also gene regulation at the RNA level. Niessing's findings about molecular and cellular networks could provide approaches to future therapy studies for the hitherto incurable disease. These have now been published in the journal Nucleic Acids Research.
Link to publication:
Molitor*, Klostermann* et al. Niessing. Nucl Acids Res (2023)
Link to press release (German):
Pressemitteilung von 20. Februar 2023