Selected Publications

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2021

Baumeister H, Paganini S, Sander LB, Lin J, Schlicker S, Terhorst Y, Moshagen M, Bengel J, Lehr D and Ebert DD. Effectiveness of a Guided Internet- and Mobile-Based Intervention for Patients with Chronic Back Pain and Depression (WARD-BP): A Multicenter, Pragmatic Randomized Controlled Trial. Psychother Psychosom. 2021; 90:255-268.

Dopler A, Stibitzky S, Hevey R, Mannes M, Guariento M, Höchsmann B, Schrezenmeier H, Ricklin D and Schmidt CQ. Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces. Front Immunol. 2021; 12:615748.

Elson A, Stein M, Rabie G, Barnea-Zohar M, Winograd-Katz S, Reuven N, Shalev M, Sekeres J, Kanaan M, Tuckermann J and Geiger B. Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis. Front Cell Dev Biol. 2021; 9:671210.

Euchner J, Sprissler J, Cathomen T, Fürst D, Schrezenmeier H, Debatin K-M, Schwarz K and Felgentreff K. Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56 bright CD16 + NKp80 +/- In-Vitro and Express KIR2DL2/DL3 and KIR3DL1 Front Immunol. 2021; 12:640672.

Kattner P, Zeiler K, Herbener VJ, Ferla-Brühl KL, Kassubek R, Grunert M, Burster T, Brühl O, Weber AS, Strobel H, Karpel-Massler G, Ott S, Hagedorn A, Tews D, Schulz A, Prasad V, Siegelin MD, Nonnenmacher L, Fischer-Posovszky P, Halatsch M-E, Debatin K-M and Westhoff M-A. What Animal Cancers teach us about Human Biology. Theranostics. 2021; 11:6682-6702.

Krämer LV, Grünzig S-D, Baumeister H, Ebert DD and Bengel J. Effectiveness of a Guided Web-Based Intervention to Reduce Depressive Symptoms before Outpatient Psychotherapy: A Pragmatic Randomized Controlled Trial. Psychother Psychosom. 2021; 90:233-242.

Reins JA, Buntrock C, Zimmermann J, Grund S, Harrer M, Lehr D, Baumeister H, Weisel K, Domhardt M, Imamura K, Kawakami N, Spek V, Nobis S, Snoek F, Cuijpers P, Klein JP, Moritz S and Ebert DD. Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials. Psychother Psychosom. 2021; 90:94-106.

Strubbe S, De Bruyne M, Pannicke U, Beyls E, Vandekerckhove B, Leclercq G, De Baere E, Bordon V, Vral A, Schwarz K, Haerynck F and Taghon T. A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair. Front Immunol. 2021; 12:674226.

Wilker S, Kolassa S, Ibrahim H, Rajan V, Pfeiffer A, Catani C and Kolassa I-T. Sex differences in PTSD risk: evidence from post-conflict populations challenges the general assumption of increased vulnerability in females. Eur J Psychotraumatol. 2021; 12:1930702.

Tuckermann J and Adams RH. The endothelium-bone axis in development, homeostasis and bone and joint disease. Nat Rev Rheumatol. 2021; 17:608-620.

Auzanneau M, Rosenbauer J, Maier W, von Sengbusch S, Hamann J, Kapellen T, Freckmann G, Schmidt S, Lilienthal E and Holl RW. Heterogeneity of Access to Diabetes Technology Depending on Area Deprivation and Demographics Between 2016 and 2019 in Germany. J Diabetes Sci Technol. 2021; 15:1059-1068.

Carleial S, Nätt D, Unternährer E, Elbert T, Robjant K, Wilker S, Vukojevic V, Kolassa I-T, Zeller AC and Koebach A. DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. Sci Rep. 2021; 11:18493.

Cherifi C, Latourte A, Vettorazzi S, Tuckermann J, Provot S, Ea H-K, Ledoux A, Casas J, Cuvillier O, Richette P, Ostertag A, Hay E and Cohen-Solal M. Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis. Osteoarthritis Cartilage. 2021; 29:1335-1345.

Crewe C, Funcke J-B, Li S, Joffin N, Gliniak CM, Ghaben AL, An YA, Sadek HA, Gordillo R, Akgul Y, Chen S, Samovski D, Fischer-Posovszky P, Kusminski CM, Klein S and Scherer PE. Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab. 2021; 33:1853-1868.e11.

Halbgebauer D, Roos J, Funcke JB, Neubauer H, Hamilton BS, Simon E, Amri EZ, Debatin KM, Wabitsch M, Fischer-Posovszky P and Tews D. Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2. Mol Metab. 2021; 53:101336.

Kamrath C, Rosenbauer J, Eckert AJ, Pappa A, Reschke F, Rohrer TR, Mönkemöller K, Wurm M, Hake K, Raile K and Holl RW. Incidence of COVID-19 and Risk of Diabetic Ketoacidosis in New-Onset Type 1 Diabetes. Pediatrics. 2021; 148.

Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA and Tuckermann J. RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk. Cell Death Differ. 2021; 28(2):700-714.

Ramo-Fernández L, Gumpp AM, Boeck C, Krause S, Bach AM, Waller C, Kolassa I-T and Karabatsiakis A. Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads. Transl Psychiatry. 2021; 11:449.

Giroud M, Tsokanos F-F, Caratti G, Kotschi S, Khani S, Jouffe C, Vogl ES, Irmler M, Glantschnig C, Gil-Lozano M, Hass D, Khan AA, Garcia MR, Mattijssen F, Maida A, Tews D, Fischer-Posovszky P, Feuchtinger A, Virtanen KA, Beckers J, Wabitsch M, Uhlenhaut H, Blüher M, Tuckermann J, Scheideler M, Bartelt A and Herzig S. HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. Diabetologia. 2021; 64:1850-1865.

Körper S, Weiss M, Zickler D, Wiesmann T, Zacharowski K, Corman VM, Grüner B, Ernst L, Spieth P, Lepper PM, Bentz M, Zinn S, Paul G, Kalbhenn J, Dollinger MM, Rosenberger P, Kirschning T, Thiele T, Appl T, Mayer B, Schmidt M, Drosten C, Wulf H, Kruse JM, Jungwirth B, Seifried E and Schrezenmeier H. Results of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients. J Clin Invest. 2021 August [Epub ahead of print].

Lanzinger S, Altug H, Schikowski T, Khodaverdi S, Rosenbauer J, Rathmann W, Praedicow K, Schönau E, Holl RW and DPV Initiative. Longitudinal relationship of particulate matter and metabolic control and severe hypoglycaemia in children and adolescents with type 1 diabetes. Environ Res. 2021; 203:111859.

Matejek N, Tittel SR, Haberland H, Rohrer T, Busemann E-M, Jorch N, Schwab K-O, Wölfle J, Holl RW and Bettendorf M. Predictors of transient congenital primary hypothyroidism: data from the German registry for congenital hypothyroidism (AQUAPE "HypoDok"). Eur J Pediatr. 2021; 180:2401-2408.

Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S and Ohlsson C. RSPO3 is important for trabecular bone and fracture risk in mice and humans. Nat Commun. 2021; 12:4923.

Prinz N, Tittel SR, Bachran R, Birnbacher R, Brückel J, Dunstheimer D, Haberland H, Hess M, Karges W, Oeverink R, Veigel A and Holl RW. Characteristics of Patients with Type 1 Diabetes and Additional Autoimmune Disease in the DPV Registry. J Clin Endocrinol Metab. 2021; 106:e3381-e3389.

Roos J, Zinngrebe J and Fischer-Posovszky P. Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance. Signal Transduct Target Ther. 2021; 6:310.

Schmidt CQ, Schrezenmeier H and Kavanagh D. Complement and the prothrombotic state. Blood. 2021 August [Epub ahead of print].

Sherr JL, Schwandt A, Phelan H, Clements MA, Holl RW, Benitez-Aguirre PZ, Miller KM, Woelfle J, Dover T, Maahs DM, Fröhlich-Reiterer E and Craig ME. Hemoglobin A1c Patterns of Youth With Type 1 Diabetes 10 Years Post Diagnosis From 3 Continents. Pediatrics. 2021; 148.

Spanhel K, Balci S, Feldhahn F, Bengel J, Baumeister H and Sander LB. Cultural adaptation of internet- and mobile-based interventions for mental disorders: a systematic review. NPJ Digit Med. 2021; 4:128.

Welters A, Tittel SR, Laubner K, Laimer M, Tschöpe D, Mader JK, Merger S, Milek S, Kummer S and Holl RW. Long-term trends of BMI and cardiometabolic risk factors among adults with type 1 diabetes: An observational study from the German/Austrian DPV registry. Diabetes Res Clin Pract. 2021; 178:108973.

Nguyen D, Simmonds P, Steenhuis M, Wouters E, Desmecht D, Garigliany M, Romano M, Barbezange C, Maes P, Van Holm B, Mendoza J, Oyonarte S, Fomsgaard A, Lassaunière R, Zusinaite E, Resman Rus K, Avšič-Županc T, Reimerink JH, Brouwer F, Hoogerwerf M, Reusken CB, Grodeland G, Le Cam S, Gallian P, Amroun A, Brisbarre N, Martinaud C, Leparc Goffart I, Schrezenmeier H, Feys HB, van der Schoot CE and Harvala H. SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data. Euro Surveill. 2021; 26.

Sattler A, Schrezenmeier E, Weber UA, Potekhin A, Bachmann F, Straub-Hohenbleicher H, Budde K, Storz E, Proß V, Bergmann Y, Thole LM, Tizian C, Hölsken O, Diefenbach A, Schrezenmeier H, Jahrsdörfer B, Zemojtel T, Jechow K, Conrad C, Lukassen S, Stauch D, Lachmann N, Choi M, Halleck F and Kotsch K. Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients. J Clin Invest. 2021; 131.

Vettorazzi S, Nalbantoglu D, Gebhardt JCM and Tuckermann J. A guide to changing paradigms of glucocorticoid receptor function-a model system for genome regulation and physiology. FEBS J. 2021 July [Epub ahead of print].

Jahrsdörfer B, Groß R, Seidel A, Wettstein L, Ludwig C, Schwarz T, Körper S, Rojewski M, Lotfi R, Weinstock C, Seifried E, Corman VM, Drosten C, Münch J and Schrezenmeier H. Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors. J Immunol. 2021; 206:2614-2622.

Rincon-Arevalo H, Choi M, Stefanski A-L, Halleck F, Weber U, Szelinski F, Jahrsdörfer B, Schrezenmeier H, Ludwig C, Sattler A, Kotsch K, Potekhin A, Chen Y, Burmester GR, Eckardt K-U, Guerra GM, Durek P, Heinrich F, Ferreira-Gomes M, Radbruch A, Budde K, Lino AC, Mashreghi M-F, Schrezenmeier E and Dörner T. Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients. Sci Immunol. 2021; 6.

Segerer H, Wurm M, Grimsmann JM, Karges B, Neu A, Sindichakis M, Warncke K, Dost A and Holl RW. Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence. Dtsch Arztebl Int. 2021; 118:367-372.

Tönshoff B, Müller B, Elling R, Renk H, Meissner P, Hengel H, Garbade SF, Kieser M, Jeltsch K, Grulich-Henn J, Euler J, Stich M, Chobanyan-Jürgens K, Zernickel M, Janda A, Wölfle L, Stamminger T, Iftner T, Ganzenmueller T, Schmitt C, Görne T, Laketa V, Olberg S, Plaszczyca A, Cortese M, Bartenschlager R, Pape C, Remme R, Huzly D, Panning M, Weigang S, Giese S, Ciminski K, Ankerhold J, Kochs G, Schwemmle M, Handgretinger R, Niemeyer CM, Engel C, Kern WV, Hoffmann GF*, Franz AR*, Henneke P*, Debatin K-M* and Kräusslich H-G*. Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany. JAMA Pediatr. 2021; 175:586-593. (*equal contribution)

Vollbach H, Auzanneau M, Reinehr T, Wiegand S, Schwab K-O, Oeverink R, Froehlich-Reiterer E, Woelfle J, De Beaufort C, Kapellen T, Gohlke B and Holl RW. Choice of basal insulin therapy is associated with weight and height development in type 1 diabetes: A multicenter analysis from the German/Austrian DPV registry in 10 338 children and adolescents. J Diabetes. 2021 June [Epub ahead of print].

Barnea-Zohar M, Winograd-Katz SE, Shalev M, Arman E, Reuven N, Roth L, Golani O, Stein M, Thalji F, Kanaan M, Tuckermann J, Geiger B and Elson A. An SNX10-dependent mechanism downregulates fusion between mature osteoclasts. J Cell Sci. 2021; 134.

Galler A, Tittel SR, Baumeister H, Reinauer C, Brosig B, Becker M, Haberland H, Hilgard D, Jivan M, Mirza J, Schwab J and Holl RW. Worse glycemic control, higher rates of diabetic ketoacidosis, and more hospitalizations in children, adolescents, and young adults with type 1 diabetes and anxiety disorders. Pediatr Diabetes. 2021; 22:519-528.

Gumpp AM, Behnke A, Bach AM, Piller S, Boeck C, Rojas R and Kolassa I-T. Mitochondrial bioenergetics in leukocytes and oxidative stress in blood serum of mild to moderately depressed women. Mitochondrion. 2021; 58:14-23.

Hoyer-Kuhn H, Huebner A, Richter-Unruh A, Bettendorf M, Rohrer T, Kapelari K, Riedl S, Mohnike K, Dörr H-G, Roehl F-W, Fink K, Holl RW and Woelfle J. Hydrocortisone dosing in children with classic congenital adrenal hyperplasia: results of the German/Austrian registry. Endocr Connect. 2021; 10:561-569.

Kamrath C, Rosenbauer J, Tittel SR, Warncke K, Hirtz R, Denzer C, Dost A, Neu A, Pacaud D and Holl RW. Frequency of Autoantibody-Negative Type 1 Diabetes in Children, Adolescents, and Young Adults During the First Wave of the COVID-19 Pandemic in Germany. Diabetes Care. 2021 May [Epub ahead of print].

Karges B, Prinz N, Placzek K, Datz N, Papsch M, Strier U, Agena D, Bonfig W, Kentrup H and Holl RW. A Comparison of Familial and Sporadic Type 1 Diabetes Among Young Patients. Diabetes Care. 2021; 44:1116-1124.

Reinehr T, Tittel SR, Holle R, Wiegand S, Gellhaus I, Hebebrand J, Greber-Platzer S, Denzer C, Linke S, Kiess W and Holl RW. Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort. Int J Obes (Lond). 2021; 45:1061-1073.

Tittel SR, Dunstheimer D, Hilgard D, Knauth B, Fröhlich-Reiterer E, Galler A, Wurm M, Holl RW and DPV Initiative. Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry. Acta Diabetol. 2021; 58:623-631.

Brixner V, Bug G, Pohler P, Krämer D, Metzner B, Voss A, Casper J, Ritter U, Klein S, Alakel N, Peceny R, Derigs HG, Stegelmann F, Wolf M, Schrezenmeier H, Thiele T, Seifried E, Kapels H-H, Döscher A, Petershofen EK, Müller TH and Seltsam A. Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial. Haematologica. 2021; 106:1086-1096.

Geirhos A, Lunkenheimer F, Holl RW, Minden K, Schmitt A, Temming S, Baumeister H and Domhardt M. Involving patients' perspective in the development of an internet- and mobile-based CBT intervention for adolescents with chronic medical conditions: Findings from a qualitative study. Internet Interv. 2021; 24:100383.

Hoffmann M, Arora P, Groß R, Seidel A, Hörnich BF, Hahn AS, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck H-M, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J and Pöhlmann S. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. Cell. 2021; 184:2384-2393.e12.

Biester T, Grimsmann JM, Heidtmann B, Rami-Merhar B, Ermer U, Wolf J, Freff M, Karges B, Agena D, Bramlage P, Danne T and Holl RW. Intermittently Scanned Glucose Values for Continuous Monitoring: Cross-Sectional Analysis of Glycemic Control and Hypoglycemia in 1809 Children and Adolescents with Type 1 Diabetes. Diabetes Technol Ther. 2021; 23:160-167.

Hartmann M, Bibli S-I, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P and Proschak E. Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator. J Med Chem. 2021; 64:2815-2828.

Hillmen P, Szer J, Weitz I, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian J-J, de Castro C, Nishimori H, Tan L, Hamdani M, Deschatelets P, Francois C, Grossi F, Ajayi T, Risitano A and de la Tour RP. Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2021; 384:1028-1037.

Jahrsdörfer B, Kroschel J, Ludwig C, Corman VM, Schwarz T, Körper S, Rojewski M, Lotfi R, Weinstock C, Drosten C, Seifried E, Stamminger T, Groß HJ and Schrezenmeier H. Independent Side-by-Side Validation and Comparison of 4 Serological Platforms for SARS-CoV-2 Antibody Testing. J Infect Dis. 2021; 223:796-801.

Kampling H, Baumeister H, Bengel J and Mittag O. Prevention of depression in adults with long-term physical conditions. Cochrane Database Syst Rev. 2021; 3:CD011246.

Lux S, Blätte TJ, Gillissen B, Richter A, Cocciardi S, Skambraks S, Schwarz K, Schrezenmeier H, Döhner H, Döhner K, Dolnik A and Bullinger L. Deregulated expression of circular RNAs in acute myeloid leukemia. Blood Adv. 2021; 5:1490-1503.

Roos J, Dahlhaus M, Funcke J-B, Kustermann M, Strauss G, Halbgebauer D, Boldrin E, Holzmann K, Möller P, Trojanowski BM, Baumann B, Debatin K-M, Wabitsch M and Fischer-Posovszky P. miR-146a regulates insulin sensitivity via NPR3. Cell Mol Life Sci. 2021; 78:2987-3003.

Auzanneau M, Karges B, Neu A, Kapellen T, Wudy SA, Grasemann C, Krauch G, Gerstl EM, Däublin G and Holl RW. Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes. Eur J Pediatr. 2021; 180:597-606.

Domhardt M, Steubl L, Boettcher J, Buntrock C, Karyotaki E, Ebert DD, Cuijpers P and Baumeister H. Mediators and mechanisms of change in internet- and mobile-based interventions for depression: A systematic review. Clin Psychol Rev. 2021; 83:101953.

Maccari ME, Fuchs S, Kury P, Andrieux G, Völkl S, Bengsch B, Lorenz MR, Heeg M, Rohr J, Jägle S, Castro CN, Groß M, Warthorst U, König C, Fuchs I, Speckmann C, Thalhammer J, Kapp FG, Seidel MG, Dückers G, Schönberger S, Schütz C, Führer M, Kobbe R, Holzinger D, Klemann C, Smisek P, Owens S, Horneff G, Kolb R, Naumann-Bartsch N, Miano M, Staniek J, Rizzi M, Kalina T, Schneider P, Erxleben A, Backofen R, Ekici A, Niemeyer CM, Warnatz K, Grimbacher B, Eibel H, Mackensen A, Frei AP, Schwarz K, Boerries M, Ehl S and Rensing-Ehl A. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J Exp Med. 2021; 218.

Addala A, Auzanneau M, Miller K, Maier W, Foster N, Kapellen T, Walker A, Rosenbauer J, Maahs DM and Holl RW. A Decade of Disparities in Diabetes Technology Use and HbA 1c in Pediatric Type 1 Diabetes: A Transatlantic Comparison Diabetes Care. 2021; 44:133-140.

Hoenig M, Roesler J, Seidel MG, Albert MH, Hauck F, Maecker-Kolhoff B, Eiz-Vesper B, Kleinschmidt K, Debatin K-M, Jacobsen E-M, Furlan I, Suttorp M, Schuetz C and Schulz AS. Matched Family Donor Lymphocyte Infusions as First Cellular Therapy for Patients with Severe Primary T Cell Deficiencies. Transplant Cell Ther. 2021; 27(1):93.e1-93.e8.

Holzer U, Döring M, Eichholz T, Ebinger M, Queudeville M, Turkiewicz D, Schwarz K, Handgretinger R, Lang P and Toporski J. Matched versus Haploidentical Hematopoietic Stem Cell Transplantation as Treatment Options for Primary Immunodeficiencies in Children. Transplant Cell Ther. 2021; 27:71.e1-71.e12.

Kamrath C, Tittel SR, Kapellen TM, von dem Berge T, Heidtmann B, Nagl K, Menzel U, Pötzsch S, Konrad K and Holl RW. Early versus delayed insulin pump therapy in children with newly diagnosed type 1 diabetes: results from the multicentre, prospective diabetes follow-up DPV registry. Lancet Child Adolesc Health. 2021; 5:17-25.

Mannes M, Dopler A, Zolk O, Lang SJ, Halbgebauer R, Höchsmann B, Skerra A, Braun CK, Huber-Lang M, Schrezenmeier H and Schmidt CQ. Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity. Blood. 2021; 137:443-455.

Nold V, Richter N, Hengerer B, Kolassa I-T and Allers KA. FKBP5 polymorphisms induce differential glucocorticoid responsiveness in primary CNS cells - First insights from novel humanized mice. Eur J Neurosci. 2021; 53:402-415.

Ramo-Fernández L, Karabatsiakis A, Boeck C, Bach AM, Gumpp AM, Mavioglu RN, Ammerpohl O and Kolassa I-T. Characterization of the effects of age and childhood maltreatment on ELOVL2 DNA methylation Dev Psychopathol. 2021 January [Epub ahead of print].

Craig-Mueller N, Hammad R, Elling R, Alzubi J, Timm B, Kolter J, Knelangen N, Bednarski C, Gläser B, Ammann S, Ivics Z, Fischer J, Speckmann C, Schwarz K, Lachmann N, Ehl S, Moritz T, Henneke P and Cathomen T. Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function. Front Immunol. 2020; 11:608802.

Hachemi Y, Rapp AE, Lee S, Dorn A-K, Krüger BT, Kaiser K, Ignatius A and Tuckermann J. Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing. Front Immunol. 2020; 11:628287.

Mytilineos D, Tsamadou C, Neuchel C, Platzbecker U, Bunjes D, Schub N, Wagner-Drouet E, Wulf G, Kröger N, Murawski N, Einsele H, Schaefer-Eckart K, Freitag S, Casper J, Kaufmann M, Dürholt M, Hertenstein B, Klein S, Ringhoffer M, Mueller CR, Frank S, Schrezenmeier H, Fuerst D and Mytilineos J. The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Analysis. Front Immunol. 2020; 11:614976.

Behnke A, Karabatsiakis A, Krumbholz A, Karrasch S, Schelling G, Kolassa I-T and Rojas R. Associating Emergency Medical Services personnel's workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair. Sci Rep. 2020; 10:22403.

Hadjadj J, Castro CN, Tusseau M, Stolzenberg M-C, Mazerolles F, Aladjidi N, Armstrong M, Ashrafian H, Cutcutache I, Ebetsberger-Dachs G, Elliott KS, Durieu I, Fabien N, Fusaro M, Heeg M, Schmitt Y, Bras M, Knight JC, Lega J-C, Lesca G, Mathieu A-L, Moreews M, Moreira B, Nosbaum A, Page M, Picard C, Ronan Leahy T, Rouvet I, Ryan E, Sanlaville D, Schwarz K, Skelton A, Viallard J-F, Viel S, Villard M, Callebaut I, Picard C, Walzer T, Ehl S, Fischer A, Neven B, Belot A and Rieux-Laucat F. Early-onset autoimmunity associated with SOCS1 haploinsufficiency. Nat Commun. 2020; 11:5341.

Kury P, Führer M, Fuchs S, Lorenz MR, Giorgetti OB, Bakhtiar S, Frei AP, Fisch P, Boehm T, Schwarz K, Speckmann C and Ehl S. Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development. EBioMedicine. 2020; 59:102961.

Cherubini V, Grimsmann JM, Åkesson K, Birkebæk NH, Cinek O, Dovč K, Gesuita R, Gregory JW, Hanas R, Hofer SE, Holl RW, Jefferies C, Joner G, King BR, Mayer-Davis EJ, Peña AS, Rami-Merhar B, Schierloh U, Skrivarhaug T, Sumnik Z, Svensson J, Warner JT, Bratina N and Dabelea D. Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents. Diabetologia. 2020; 63:1530-1541.

Niehues T, Özgür TT, Bickes M, Waldmann R, Schöning J, Bräsen J, Hagel C, Ballmaier M, Klusmann J-H, Niedermayer A, Pannicke U, Enders A, Dückers G, Siepermann K, Hempel J, Schwarz K* and Viemann D*. Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre-excitation syndrome. Eur J Immunol. 2020; 50:1078-1080. (*contributed equally)

Dost A, Bechtold S, Fink K, Bonfig W, Wiemann D, Kapellen TM, Witsch M, Schwab KO, Holl RW, for the initiative DPV-Science and the German Diabetes Research Center. 2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes. Diabetes Care. 2020; 43:1311-1318.

Wegehaupt O, Groß M, Wehr C, Marks R, Schmitt-Graeff A, Uhl M, Lorenz M, Schwarz K, Kratz C, Niemeyer C and Ehl S. TIM-3 deficiency presenting with two clonally unrelated episodes of mesenteric and subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2020; 67:e28302.

Heller S, Kölsch U, Magg T, Krüger R, Scheuern A, Schneider H, Eichinger A, Wahn V, Unterwalder N, Lorenz M, Schwarz K, Meisel C, Schulz A, Hauck F and von Bernuth H. T Cell Impairment Is Predictive for a Severe Clinical Course in NEMO Deficiency. J Clin Immunol. 2020; 40:421-434.

Tauschmann M, Hermann JM, Freiberg C, Papsch M, Thon A, Heidtmann B, Placzeck K, Agena D, Kapellen TM, Schenk B, Wolf J, Danne T, Rami-Merhar B and Holl RW on behalf of the DPV Initiative. Reduction in Diabetic Ketoacidosis and Severe Hypoglycemia in Pediatric Type 1 Diabetes During the First Year of Continuous Glucose Monitoring: A Multicenter Analysis of 3,553 Subjects From the DPV Registry. Diabetes Care. 2020; 43:e40-e42.

Łyszkiewicz M, Ziętara N, Frey L, Pannicke U, Stern M, Liu Y, Fan Y, Puchałka J, Hollizeck S, Somekh I, Rohlfs M, Yilmaz T, Ünal E, Karakukcu M, Patiroğlu T, Kellerer C, Karasu E, Sykora K-W, Lev A, Simon A, Somech R, Roesler J, Hoenig M, Keppler OT, Schwarz K and Klein C. Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells. Nat Commun. 2020; 11:1031.

Jägle S, Heeg M, Grün S, Rensing-Ehl A, Maccari ME, Klemann C, Jones N, Lehmberg K, Bettoni C, Warnatz K, Grimbacher B, Biebl A, Schauer U, Hague R, Neth O, Mauracher A, Pachlopnik Schmid J, Fabre A, Kostyuchenko L, Führer M, Lorenz MR, Schwarz K, Rohr J and Ehl S. Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity. Clin Immunol. 2020; 210:108316.

Krüger R, Baumann U, Borte S, Kölsch U, Lorenz MR, Keller B, Harder I, Warnatz K, Ehl S, Schwarz K, Wahn V and von Bernuth H. Impaired polysaccharide responsiveness without agammaglobulinaemia in three patients with hypomorphic mutations in Bruton Tyrosine Kinase-No detection by newborn screening for primary immunodeficiencies. Scand J Immunol. 2020; 91:e12811.

Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M*, Kühnen P*; for the Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020; 8:960-970. (*shared last author)

Domhardt M, Steubl L and Baumeister H. Internet- and Mobile-Based Interventions for Mental and Somatic Conditions in Children and Adolescents. Z Kinder Jugendpsychiatr Psychother. 2020; 48:33-46.

Fathzadeh M, Li J, Rao A, Cook N, Chennamsetty I, Seldin M, Zhou X, Sangwung P, Gloudemans MJ, Keller M, Attie A, Yang J, Wabitsch M, Carcamo-Orive I, Tada Y, Lusis AJ, Shin MK, Molony CM, McLaughlin T, Reaven G, Montgomery SB, Reilly D, Quertermous T, Ingelsson E and Knowles JW. FAM13A affects body fat distribution and adipocyte function. Nat Commun. 2020; 11:1465.

Fegert JM, Vitiello B, Plener PL and Clemens V. Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normality. Child Adolesc Psychiatry Ment Health. 2020; 14:20.

Grimsmann JM, von Sengbusch S, Freff M, Ermer U, Placzek K, Danne T, Hammer E and Holl RW; for the DPV Initiative. Glucose Management Indicator Based on Sensor Data and Laboratory HbA(1c) in People With Type 1 Diabetes From the DPV Database: Differences by Sensor Type. Diabetes Care. 2020; 43:e111-e112.

Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa I-T* and Karabatsiakis A*. Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A. 2020; 117:24778-24784. (*contributed equally)

Kamrath C, Mönkemöller K, Biester T, Rohrer TR, Warncke K, Hammersen J and Holl RW. Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany. JAMA. 2020; 324:801-804.

Kraft R, Schlee W, Stach M, Reichert M, Langguth B, Baumeister H, Probst T, Hannemann R and Pryss R. Combining Mobile Crowdsensing and Ecological Momentary Assessments in the Healthcare Domain. Front Neurosci. 2020; 14:164.

Lausser L, Szekely R, Klimmek A, Schmid F and Kestler HA. Constraining classifiers in molecular analysis: invariance and robustness. J R Soc Interface. 2020; 17:20190612.

Lunkenheimer F, Domhardt M, Geirhos A, Kilian R, Mueller-Stierlin AS, Holl RW, Meissner T, Minden K, Moshagen M, Ranz R, Sachser C, Staab D, Warschburger P and Baumeister H; for the COACH consortium. Effectiveness and cost-effectiveness of guided Internet- and mobile-based CBT for adolescents and young adults with chronic somatic conditions and comorbid depression and anxiety symptoms (youthCOACH(CD)): study protocol for a multicentre randomized controlled trial. Trials. 2020; 21:253.

Orzechowski M, Nowak M, Bielińska K, Chowaniec A, Doričić R, Ramšak M, Łuków P, Muzur A, Zupanič-Slavec Z and Steger F. Social diversity and access to healthcare in Europe: how does European Union's legislation prevent from discrimination in healthcare? BMC Public Health. 2020; 20:1399.

Orzechowski M, Schochow M, Kühl M and Steger F. Donor information in research and drug evaluation with induced pluripotent stem cells (iPSCs). Stem Cell Res Ther. 2020; 11:126.

Pryss R, Schlee W, Hoppenstedt B, Reichert M, Spiliopoulou M, Langguth B, Breitmayer M and Probst T. Applying Machine Learning to Daily-Life Data From the TrackYourTinnitus Mobile Health Crowdsensing Platform to Predict the Mobile Operating System Used With High Accuracy: Longitudinal Observational Study. J Med Internet Res. 2020; 22:e15547.

Reisser T, Halbgebauer D, Scheurer J, Wolf L, Leithäuser F, Beyersdorf N, Fischer-Posovszky P, Debatin K-M and Strauss G. In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease. Leukemia. 2020; 34:1943-1948.

Sander LB, Paganini S, Terhorst Y, Schlicker S, Lin J, Spanhel K, Buntrock C, Ebert DD and Baumeister H. Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial. JAMA Psychiatry. 2020; 77:1001-1011.

Scheurer J, Reisser T, Leithäuser F, Messmann JJ, Holzmann K, Debatin K-M and Strauss G. Rapamycin-based graft-versus-host disease prophylaxis increases the immunosuppressivity of myeloid-derived suppressor cells without affecting T cells and anti-tumor cytotoxicity. Clin Exp Immunol. 2020; 202:407-422.

Tittel SR, Rosenbauer J, Kamrath C, Ziegler J, Reschke F, Hammersen J, Mönkemöller K, Pappa A, Kapellen T and Holl RW; for the DPV Initiative. Did the COVID-19 Lockdown Affect the Incidence of Pediatric Type 1 Diabetes in Germany? Diabetes Care. 2020; 43:e172-e173.

Wabitsch M, V Schnurbein J, Vollbach H, Lennerz B, Weyhreter H, Wiegand S, Kiess W, Hebebrand J and Brandt S. [Innovative medical care concepts for adolescents with severe obesity]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020; 63:831-838.

Wunderlich AP, Schmidt SA, Mauro V, Kneller L, Kannengießer S, Beer M and Cario H. Liver Iron Content Determination Using a Volumetric Breath-Hold Gradient-Echo Sequence With In-Line R(2) * Calculation. J Magn Reson Imaging. 2020; 52:1550-1556.

Zinngrebe J, Debatin K-M and Fischer-Posovszky P. Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders? Leukemia. 2020; 34:2305-2316.

Zinngrebe J, Schlichtig F, Kraus JM, Meyer M, Boldrin E, Kestler HA, Meyer L-H, Fischer-Posovszky P and Debatin K-M. Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia. Int J Cancer. 2020; 146:3219-3231.

Baumeister H and Montag C (Eds.). Digital Phenotyping and Mobile Sensing: New Developments in Psychoinformatics 2019; Cham: Springer Nature.

Braig S, Stalder T, Kirschbaum C, Rothenbacher D and Genuneit J. The association of potential stressors with hair steroids in parents with small children: The Ulm SPATZ health study. Psychoneuroendocrinology. 2019; 102:37-43.

El-Helou SM, Biegner A-K, Bode S, Ehl SR, Heeg M, Maccari ME, Ritterbusch H, Speckmann C, Rusch S, Scheible R, Warnatz K, Atschekzei F, Beider R, Ernst D, Gerschmann S, Jablonka A, Mielke G, Schmidt RE, Schürmann G, Sogkas G, Baumann UH, Klemann C, Viemann D, von Bernuth H, Krüger R, Hanitsch LG, Scheibenbogen CM, Wittke K, Albert MH, Eichinger A, Hauck F, Klein C, Rack-Hoch A, Sollinger FM, Avila A, Borte M, Borte S, Fasshauer M, Hauenherm A, Kellner N, Müller AH, Ülzen A, Bader P, Bakhtiar S, Lee J-Y, Heß U, Schubert R, Wölke S, Zielen S, Ghosh S, Laws H-J, Neubert J, Oommen PT, Hönig M, Schulz A, Steinmann S, Schwarz K, Dückers G, Lamers B, Langemeyer V, Niehues T, Shai S, Graf D, Müglich C, Schmalzing MT, Schwaneck EC, Tony H-P, Dirks J, Haase G, Liese JG, Morbach H, Foell D, Hellige A, Wittkowski H, Masjosthusmann K, Mohr M, Geberzahn L, Hedrich CM, Müller C, Rösen-Wolff A, Roesler J, Zimmermann A, Behrends U, Rieber N, Schauer U, Handgretinger R, Holzer U, Henes J, Kanz L, Boesecke C, Rockstroh JK, Schwarze-Zander C, Wasmuth J-C, Dilloo D, Hülsmann B, Schönberger S, Schreiber S, Zeuner R, Ankermann T, von Bismarck P, Huppertz H-I, Kaiser-Labusch P, Greil J, Jakoby D, Kulozik AE, Metzler M, Naumann-Bartsch N, Sobik B, Graf N, Heine S, Kobbe R, Lehmberg K, Müller I, Herrmann F, Horneff G, Klein A, Peitz J, Schmidt N, Bielack S, Groß-Wieltsch U, Classen CF, Klasen J, Deutz P, Kamitz D, Lassay L, Tenbrock K, Wagner N, Bernbeck B, Brummel B, Lara-Villacanas E, Münstermann E, Schneider DT, Tietsch N, Westkemper M, Weiß M, Kramm C, Kühnle I, Kullmann S, Girschick H, Specker C, Vinnemeier-Laubenthal E, Haenicke H, Schulz C, Schweigerer L, Müller TG, Stiefel M, Belohradsky BH, Soetedjo V, Kindle G and Grimbacher B. The German National Registry of Primary Immunodeficiencies (2012-2017). Front Immunol. 2019; 10:1272.

Giesselmann P, Brändl B, Raimondeau E, Bowen R, Rohrandt C, Tandon R, Kretzmer H, Assum G, Galonska C, Siebert R, Ammerpohl O, Heron A, Schneider SA, Ladewig J, Koch P, Schuldt BM, Graham JE, Meissner A and Müller F-J. Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing. Nat Biotechnol. 2019; 37:1478-1481.

Groß A, Kracher B, Kraus JM, Kühlwein SD, Pfister AS, Wiese S, Luckert K, Pötz O, Joos T, Van Daele D, De Raedt L, Kühl M and Kestler HA. Representing dynamic biological networks with multi-scale probabilistic models. Commun Biol. 2019; 2:21.

Hellmuth C, Kirchberg FF, Brandt S, Moß A, Walter V, Rothenbacher D, Brenner H, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Luque V, Verduci E, Mariani B, Langhendries J-P, Poncelet P, Heinrich J, Lehmann I, Standl M, Uhl O, Koletzko B, Thiering E and Wabitsch M. An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children. Sci Rep. 2019; 9:5053.

Höchsmann B, Murakami Y, Osato M, Knaus A, Kawamoto M, Inoue N, Hirata T, Murata S, Anliker M, Eggermann T, Jäger M, Floettmann R, Höllein A, Murase S, Ueda Y, Nishimura J-I, Kanakura Y, Kohara N, Schrezenmeier H*, Krawitz PM* and Kinoshita T*. Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation. J Clin Invest. 2019; 129:5123-5136. (*contributed equally)

Hoffmann B, Kobel S, Wartha O, Kettner S, Dreyhaupt J and Steinacker JM. High sedentary time in children is not only due to screen media use: a cross-sectional study. BMC Pediatr. 2019; 19:154.

Iype J, Datta M, Khadour A, Übelhart R, Nicolò A, Rollenske T, Dühren-von Minden M, Wardemann H, Maity PC and Jumaa H. Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor. J Immunol. 2019; 202:1417-1427.

Kobel S, Wartha O, Dreyhaupt J, Kettner S and Steinacker JM. Cross-sectional associations of objectively assessed sleep duration with physical activity, BMI and television viewing in German primary school children. BMC Pediatr. 2019; 19:54.

Kobel S, Wartha O, Lämmle C, Dreyhaupt J and Steinacker JM. Intervention effects of a kindergarten-based health promotion programme on obesity related behavioural outcomes and BMI percentiles. Prev Med Rep. 2019; 15:100931.

Lausser L, Schäfer LM, Schirra L-R, Szekely R, Schmid F and Kestler HA. Assessing phenotype order in molecular data. Sci Rep. 2019; 9:11746.

Lee JW, Sicre de Fontbrune F, Wong Lee Lee L, Pessoa V, Gualandro S, Füreder W, Ptushkin V, Rottinghaus ST, Volles L, Shafner L, Aguzzi R, Pradhan R, Schrezenmeier H and Hill A. Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study. Blood. 2019; 133:530-539.

Lennerz BS, Moss A, von Schnurbein J, Bickenbach A, Bollow E, Brandt S, Luetke-Brintrup D, Mühlig Y, Neef M, Ose C, Remy M, Stark R, Teuner C, Wolters B, Kiess W, Scherag A, Reinehr T, Holl RW, Holle R, Wiegand S, Hebebrand J and Wabitsch M. Do adolescents with extreme obesity differ according to previous treatment seeking behavior? The Youth with Extreme obesity Study (YES) cohort. Int J Obes (Lond). 2019; 43:103-115.

López C, Kleinheinz K, Aukema SM, Rohde M, Bernhart SH, Hübschmann D, Wagener R, Toprak UH, Raimondi F, Kreuz M, Waszak SM, Huang Z, Sieverling L, Paramasivam N, Seufert J, Sungalee S, Russell RB, Bausinger J, Kretzmer H, Ammerpohl O, Bergmann AK, Binder H, Borkhardt A, Brors B, Claviez A, Doose G, Feuerbach L, Haake A, Hansmann M-L, Hoell J, Hummel M, Korbel JO, Lawerenz C, Lenze D, Radlwimmer B, Richter J, Rosenstiel P, Rosenwald A, Schilhabel MB, Stein H, Stilgenbauer S, Stadler PF, Szczepanowski M, Weniger MA, Zapatka M, Eils R, Lichter P, Loeffler M, Möller P, Trümper L, Klapper W, Hoffmann S, Küppers R, Burkhardt B, Schlesner M and Siebert R. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nat Commun. 2019; 10:1459.

Nolkemper D, Wiggert N, Müller S, Fegert JM and Kölch M. [Participation and Information in Child and Youth Psychiatry]. Prax Kinderpsychol Kinderpsychiatr. 2019; 68:271-285.

Rojewski MT, Lotfi R, Gjerde C, Mustafa K, Veronesi E, Ahmed AB, Wiesneth M, Körper S, Sensebé L, Layrolle P, Hellem S and Schrezenmeier H. Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data. Cytotherapy. 2019; 21:468-482.

Rubeis G and Steger F. Saving whom? The ethical challenges of harvesting tissue from savior siblings. Eur J Haematol. 2019; 103:478-482.

Rubeis G and Steger F. A burden from birth? Non-invasive prenatal testing and the stigmatization of people with disabilities. Bioethics. 2019; 33:91-97.

Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M and Jumaa H. Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR. EMBO J. 2019; 38.

Tews D, Pula T, Funcke JB, Jastroch M, Keuper M, Debatin K-M, Wabitsch M and Fischer-Posovszky P. Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Redox Biol. 2019; 26:101286.

Volpi S, Cicalese MP, Tuijnenburg P, Tool ATJ, Cuadrado E, Abu-Halaweh M, Ahanchian H, Alzyoud R, Akdemir ZC, Barzaghi F, Blank A, Boisson B, Bottino C, Brigida I, Caorsi R, Casanova J-L, Chiesa S, Chinn IK, Dückers G, Enders A, Erichsen HC, Forbes LR, Gambin T, Gattorno M, Karimiani EG, Giliani S, Gold MS, Jacobsen E-M, Jansen MH, King JR, Laxer RM, Lupski JR, Mace E, Marcenaro S, Maroofian R, Meijer AB, Niehues T, Notarangelo LD, Orange J, Pannicke U, Pearson C, Picco P, Quinn PJ, Schulz A, Seeborg F, Stray-Pedersen A, Tawamie H, van Leeuwen EMM, Aiuti A, Yeung R, Schwarz K and Kuijpers TW. A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency. J Allergy Clin Immunol. 2019; 143:2296-2299.

Ballmann M, Hubert D, Assael BM, Staab D, Hebestreit A, Naehrlich L, Nickolay T, Prinz N and Holl RW; for the CFRD Study Group. Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol. 2018; 6:114-121.

Bendig E, Bauereiß N, Ebert DD, Snoek F, Andersson G and Baumeister H. Internet-Based Interventions in Chronic Somatic Disease. Dtsch Arztebl Int. 2018; 115:659-665.

Boege I, Herrmann J, Wolff JK, Hoffmann U, Koelch M, Kurepkat M, Lütte S, Naumann A, Nolting HD and Fegert JM. CCSchool: a multicentre, prospective study on improving continuum of care in children and adolescents with mental health problems associated with school problems in Germany. BMC Health Serv Res. 2018; 18:947.

Braig S, Genuneit J, Walter V, Brandt S, Wabitsch M, Goldbeck L, Brenner H and Rothenbacher D. Screen Time, Physical Activity and Self-Esteem in Children: The Ulm Birth Cohort Study. Int J Environ Res Public Health. 2018; 15.

Clemens V, Huber-Lang M, Plener PL, Brähler E, Brown RC and Fegert JM. Association of child maltreatment subtypes and long-term physical health in a German representative sample. Eur J Psychotraumatol. 2018; 9:1510278.

Imkeller K, Scally SW, Bosch A, Martí GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordmüller B, Levashina EA, Julien J-P and Wardemann H. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science. 2018; 360:1358-1362.

Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U and Tuckermann JP. Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis. Ann Rheum Dis. 2018; 77:1610-1618.

Koenig AM, Karabatsiakis A, Stoll T, Wilker S, Hennessy T, Hill MM and Kolassa I-T. Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study. Sci Rep. 2018; 8:3468.

Kohlsdorf K, Nunziata A, Funcke J-B, Brandt S, von Schnurbein J, Vollbach H, Lennerz B, Fritsch M, Greber-Platzer S, Fröhlich-Reiterer E, Luedeke M, Borck G, Debatin K-M, Fischer-Posovszky P and Wabitsch M. Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency. Int J Obes (Lond). 2018; 42:1602-1609.

Kraus JM, Lausser L, Kuhn P, Jobst F, Bock M, Halanke C, Hummel M, Heuschmann P and Kestler HA. Big data and precision medicine: challenges and strategies with healthcare data. Int J Data Sci Anal. 2018; 6(3):241-249.

Lausser L, Szekely R, Schirra L-R and Kestler HA. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett. 2018; 48(2, SI):863-880.

Lenglet M, Robriquet F, Schwarz K, Camps C, Couturier A, Hoogewijs D, Buffet A, Knight SJL, Gad S, Couvé S, Chesnel F, Pacault M, Lindenbaum P, Job S, Dumont S, Besnard T, Cornec M, Dreau H, Pentony M, Kvikstad E, Deveaux S, Burnichon N, Ferlicot S, Vilaine M, Mazzella J-M, Airaud F, Garrec C, Heidet L, Irtan S, Mantadakis E, Bouchireb K, Debatin K-M, Redon R, Bezieau S, Bressac-de Paillerets B, Teh BT, Girodon F, Randi M-L, Putti MC, Bours V, Van Wijk R, Göthert JR, Kattamis A, Janin N, Bento C, Taylor JC, Arlot-Bonnemains Y, Richard S, Gimenez-Roqueplo A-P, Cario H and Gardie B. Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease. Blood. 2018; 132:469-483.

Rubeis G, Schochow M and Steger F. Patient Autonomy and Quality of Care in Telehealthcare. Sci Eng Ethics. 2018; 24:93-107.

Schickler M, Pryss R, Schlee W, Probst T, Langguth B, Schobel J and Reichert M. Usability Study on Mobile Processes Enabling Remote Therapeutic Interventions. 31st IEEE Int Symp on Computer-Based Medical Systems. 2018; 146-151.

Schobel J, Pryss R, Probst T, Schlee W, Schickler M and Reichert M. Learnability of a Configurator Empowering End Users to Create Mobile Data Collection Instruments: Usability Study. JMIR Mhealth Uhealth. 2018; 6:e148.

Bohn B, Wiegand S, Kiess W, Reinehr T, Stachow R, Oepen J, Langhof H, Hermann T, Widhalm K, Wabitsch M, Gellhaus I, Holl RW; for the APV Initiative and the German Competence Network Obesity. Changing Characteristics of Obese Children and Adolescents Entering Pediatric Lifestyle Intervention Programs in Germany over the Last 11 Years: An Adiposity Patients Registry Multicenter Analysis of 65,453 Children and Adolescents. Obesity facts. 2017; 10:517-530.

Hoenig M, Lagresle-Peyrou C, Pannicke U, Notarangelo LD, Porta F, Gennery AR, Slatter M, Cowan MJ, Stepensky P, Al-Mousa H, Al-Zahrani D, Pai S-Y, Al Herz W, Gaspar HB, Veys P, Oshima K, Imai K, Yabe H, Noroski LM, Wulffraat NM, Sykora K-W, Soler-Palacin P, Muramatsu H, Al Hilali M, Moshous D, Debatin K-M, Schuetz C, Jacobsen E-M, Schulz AS, Schwarz K, Fischer A, Friedrich W and Cavazzana M; for the European Society for Blood and Marrow Transplantation (EBMT) Inborn Errors Working Party. Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome. Blood. 2017; 129:2928-2938.

Karges B, Schwandt A, Heidtmann B, Kordonouri O, Binder E, Schierloh U, Boettcher C, Kapellen T, Rosenbauer J and Holl RW. Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes. JAMA. 2017; 318:1358-1366.

Kesztyüs D, Lauer R, Kesztyüs T, Kilian R and Steinacker JM; for the “Join the Healthy Boat” Study Group. Costs and effects of a state-wide health promotion program in primary schools in Germany - the Baden-Württemberg Study: A cluster-randomized, controlled trial. PLoS One. 2017; 12:e0172332.

Knuplesch D, Reichert M and Kumar A. A framework for visually monitoring business process compliance. Inf Syst. 2017; 64:381-409.

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP* and Moriggl R*. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes. 2017; 66:272-286. (*equal contribution and correspondence)

Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, Köhler R, Barth TFE, Te Kronnie G, Debatin K-M* and Meyer L-H*. Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor. Blood. 2017; 130:643-654. (*shared senior authorship)

Wahl S, Drong A, Lehne B, Loh M, Scott WR, Kunze S, Tsai P-C, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, Kriebel J, Richmond RC, Adamo M, Afzal U, Ala-Korpela M, Albetti B, Ammerpohl O, Apperley JF, Beekman M, Bertazzi PA, Black SL, Blancher C, Bonder M-J, Brosch M, Carstensen-Kirberg M, de Craen AJM, de Lusignan S, Dehghan A, Elkalaawy M, Fischer K, Franco OH, Gaunt TR, Hampe J, Hashemi M, Isaacs A, Jenkinson A, Jha S, Kato N, Krogh V, Laffan M, Meisinger C, Meitinger T, Mok ZY, Motta V, Ng HK, Nikolakopoulou Z, Nteliopoulos G, Panico S, Pervjakova N, Prokisch H, Rathmann W, Roden M, Rota F, Rozario MA, Sandling JK, Schafmayer C, Schramm K, Siebert R, Slagboom PE, Soininen P, Stolk L, Strauch K, Tai E-S, Tarantini L, Thorand B, Tigchelaar EF, Tumino R, Uitterlinden AG, van Duijn C, van Meurs JBJ, Vineis P, Wickremasinghe AR, Wijmenga C, Yang T-P, Yuan W, Zhernakova A, Batterham RL, Smith GD, Deloukas P, Heijmans BT, Herder C, Hofman A, Lindgren CM, Milani L, van der Harst P, Peters A, Illig T, Relton CL, Waldenberger M, Järvelin M-R, Bollati V, Soong R, Spector TD, Scott J, McCarthy MI, Elliott P, Bell JT, Matullo G, Gieger C, Kooner JS, Grallert H and Chambers JC. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature. 2017; 541:81-86.

Bens S, Kolarova J, Beygo J, Buiting K, Caliebe A, Eggermann T, Gillessen-Kaesbach G, Prawitt D, Thiele-Schmitz S, Begemann M, Enklaar T, Gutwein J, Haake A, Paul U, Richter J, Soellner L, Vater I, Monk D, Horsthemke B, Ammerpohl O and Siebert R. Phenotypic spectrum and extent of DNA methylation defects associated with multilocus imprinting disturbances. Epigenomics. 2016; 8:801-16.

Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E and Kolassa I-T. Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion. 2016; 30:197-207.

Felgentreff K, Baxi SN, Lee YN, Dobbs K, Henderson LA, Csomos K, Tsitsikov EN, Armanios M, Walter JE and Notarangelo LD. Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals. J Clin Immunol. 2016; 36:341-53.

Kyu HH, Pinho C, Wagner JA, Brown JC, Bertozzi-Villa A, Charlson FJ, Coffeng LE, Dandona L, Erskine HE, Ferrari AJ, Fitzmaurice C, Fleming TD, Forouzanfar MH, Graetz N, Guinovart C, Haagsma J, Higashi H, Kassebaum NJ, Larson HJ, Lim SS, Mokdad AH, Moradi-Lakeh M, Odell SV, Roth GA, Serina PT, Stanaway JD, Misganaw A, Whiteford HA, Wolock TM, Wulf Hanson S, Abd-Allah F, Abera SF, Abu-Raddad LJ, AlBuhairan FS, Amare AT, Antonio CAT, Artaman A, Barker-Collo SL, Barrero LH, Benjet C, Bensenor IM, Bhutta ZA, Bikbov B, Brazinova A, Campos-Nonato I, Castañeda-Orjuela CA, Catalá-López F, Chowdhury R, Cooper C, Crump JA, Dandona R, Degenhardt L, Dellavalle RP, Dharmaratne SD, Faraon EJA, Feigin VL, Fürst T, Geleijnse JM, Gessner BD, Gibney KB, Goto A, Gunnell D, Hankey GJ, Hay RJ, Hornberger JC, Hosgood HD, Hu G, Jacobsen KH, Jayaraman SP, Jeemon P, Jonas JB, Karch A, Kim D, Kim S, Kokubo Y, Kuate Defo B, Kucuk Bicer B, Kumar GA, Larsson A, Leasher JL, Leung R, Li Y, Lipshultz SE, Lopez AD, Lotufo PA, Lunevicius R, Lyons RA, Majdan M, Malekzadeh R, Mashal T, Mason-Jones AJ, Melaku YA, Memish ZA, Mendoza W, Miller TR, Mock CN, Murray J, Nolte S, Oh I-H, Olusanya BO, Ortblad KF, Park E-K, Paternina Caicedo AJ, Patten SB, Patton GC, Pereira DM, Perico N, Piel FB, Polinder S, Popova S, Pourmalek F, Quistberg DA, Remuzzi G, Rodriguez A, Rojas-Rueda D, Rothenbacher D, Rothstein DH, Sanabria J, Santos IS, Schwebel DC, Sepanlou SG, Shaheen A, Shiri R, Shiue I, Skirbekk V, Sliwa K, Sreeramareddy CT, Stein DJ, Steiner TJ, Stovner LJ, Sykes BL, Tabb KM, Terkawi AS, Thomson AJ, Thorne-Lyman AL, Towbin JA, Ukwaja KN, Vasankari T, Venketasubramanian N, Vlassov VV, Vollset SE, Weiderpass E, Weintraub RG, Werdecker A, Wilkinson JD, Woldeyohannes SM, Wolfe CDA, Yano Y, Yip P, Yonemoto N, Yoon S-J, Younis MZ, Yu C, El Sayed Zaki M, Naghavi M, Murray CJL and Vos T. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study. JAMA Pediatr. 2016; 170:267-87.

Logan C, Zittel T, Striebel S, Reister F, Brenner H, Rothenbacher D and Genuneit J. Changing Societal and Lifestyle Factors and Breastfeeding Patterns Over Time. Pediatrics. 2016; 137.

Roos J, Enlund E, Funcke J-B, Tews D, Holzmann K, Debatin K-M, Wabitsch M and Fischer-Posovszky P. miR-146a-mediated suppression of the inflammatory response in human adipocytes. Sci Rep. 2016; 6:38339.

Braig S, Grabher F, Ntomchukwu C, Reister F, Stalder T, Kirschbaum C, Genuneit J and Rothenbacher D. Determinants of maternal hair cortisol concentrations at delivery reflecting the last trimester of pregnancy. Psychoneuroendocrinology. 2015; 52:289-96.

Brandt S, Moß A, Koenig W, Rothenbacher D, Brenner H and Wabitsch M. Intrafamilial associations of cardiometabolic risk factors--results of the Ulm Birth Cohort Study. Atherosclerosis. 2015; 240:174-183.

Dobbs K, Domínguez Conde C, Zhang S-Y, Parolini S, Audry M, Chou J, Haapaniemi E, Keles S, Bilic I, Okada S, Massaad MJ, Rounioja S, Alwahadneh AM, Serwas NK, Capuder K, Çiftçi E, Felgentreff K, Ohsumi TK, Pedergnana V, Boisson B, Haskoloğlu Ş, Ensari A, Schuster M, Moretta A, Itan Y, Patrizi O, Rozenberg F, Lebon P, Saarela J, Knip M, Petrovski S, Goldstein DB, Parrott RE, Savas B, Schambach A, Tabellini G, Bock C, Chatila TA, Comeau AM, Geha RS, Abel L, Buckley RH, İkincioğulları A, Al-Herz W, Helminen M, Doğu F, Casanova J-L, Boztuğ K and Notarangelo LD. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015; 372:2409-22.

Dyke SOM, Cheung WA, Joly Y, Ammerpohl O, Lutsik P, Rothstein MA, Caron M, Busche S, Bourque G, Rönnblom L, Flicek P, Beck S, Hirst M, Stunnenberg H, Siebert R, Walter J and Pastinen T. Epigenome data release: a participant-centered approach to privacy protection. Genome Biol. 2015; 16:142.

Felgentreff K, Lee YN, Frugoni F, Du L, van der Burg M, Giliani S, Tezcan I, Reisli I, Mejstrikova E, de Villartay J-P, Sleckman BP, Manis J and Notarangelo LD. Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency. J Allergy Clin Immunol. 2015; 136:140-150.e7.

Kelly RJ, Höchsmann B, Szer J, Kulasekararaj A, de Guibert S, Röth A, Weitz IC, Armstrong E, Risitano AM, Patriquin CJ, Terriou L, Muus P, Hill A, Turner MP, Schrezenmeier H and Peffault de Latour R. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2015; 373:1032-9.

Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S and Radlwimmer B. DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. Nat Genet. 2015; 47:1316-1325.

Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M, Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee S-T, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E and Martín-Subero JI. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015; 47:746-756.

Messmann JJ, Reisser T, Leithäuser F, Lutz MB, Debatin K-M and Strauss G. In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity. Blood. 2015; 126:1138-48.

Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AHC, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M and Jumaa H. Responsiveness of B cells is regulated by the hinge region of IgD. Nat Immunol. 2015; 16:534-43.

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David J-P, Gräler M, Kleiman A and Tuckermann JP. Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun. 2015; 6:7796.

Wabitsch M, Funcke J-B, Lennerz B, Kuhnle-Krahl U, Lahr G, Debatin K-M, Vatter P, Gierschik P, Moepps B and Fischer-Posovszky P. Biologically inactive leptin and early-onset extreme obesity. N Engl J Med. 2015; 372:48-54.

Bento C, Percy MJ, Gardie B, Maia TM, van Wijk R, Perrotta S, Della Ragione F, Almeida H, Rossi C, Girodon F, Aström M, Neumann D, Schnittger S, Landin B, Minkov M, Randi ML, Richard S, Casadevall N, Vainchenker W, Rives S, Hermouet S, Ribeiro ML, McMullin MF, Cario H, Chauveau A, Gimenez-Roqueplo A-P, Bressac-de-Paillerets B, Altindirek D, Lorenzo F, Lambert F, Dan H, Gad-Lapiteau S, Catarina Oliveira A, Rossi C, Fraga C, Taradin G, Martin-Nuñez G, Vitória H, Diaz Aguado H, Palmblad J, Vidán J, Relvas L, Ribeiro ML, Luigi Larocca M, Luigia Randi M, Pedro Silveira M, Percy M, Gross M, Marques da Costa R, Beshara S, Ben-Ami T and Ugo V. Genetic basis of congenital erythrocytosis: mutation update and online databases. Hum Mutat. 2014; 35:15-26.

Felgentreff K, Du L, Weinacht KG, Dobbs K, Bartish M, Giliani S, Schlaeger T, DeVine A, Schambach A, Woodbine LJ, Davies G, Baxi SN, van der Burg M, Bleesing J, Gennery A, Manis J, Pan-Hammarström Q and Notarangelo LD. Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014; 111:8889-94.

Höchsmann B, Dohna-Schwake C, Kyrieleis HA, Pannicke U and Schrezenmeier H. Targeted therapy with eculizumab for inherited CD59 deficiency. N Engl J Med. 2014; 370:90-2.

Karabatsiakis A, Böck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE and Kolassa I-T. Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry. 2014; 4:e397.

Lennerz BS, Wabitsch M, Lippert H, Wolff S, Knoll C, Weiner R, Manger T, Kiess W and Stroh C. Bariatric surgery in adolescents and young adults--safety and effectiveness in a cohort of 345 patients. Int J Obes (Lond). 2014; 38:334-340.

Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, Elbert T, Bürkle A and Kolassa I-T. Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress. Psychother Psychosom. 2014; 83:289-297.

Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, Damm-Welk C, Drexler HG, Hummel M, Jaffe ES, Küppers R, Lefebvre C, Lisfeld J, Löffler M, Macleod RAF, Nagel I, Oschlies I, Rosolowski M, Russell RB, Rymkiewicz G, Schindler D, Schlesner M, Scholtysik R, Schwaenen C, Spang R, Szczepanowski M, Trümper L, Vater I, Wessendorf S, Klapper W and Siebert R; for the Molecular Mechanisms in Malignant Lymphoma Network Project and Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group. A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood. 2014; 123:1187-98.

Ahrens M*, Ammerpohl O*, von Schönfels W*, Kolarova J, Bens S, Itzel T, Teufel A, Herrmann A, Brosch M, Hinrichsen H, Erhart W, Egberts J, Sipos B, Schreiber S, Häsler R, Stickel F, Becker T, Krawczak M, Röcken C, Siebert R, Schafmayer C and Hampe J. DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab. 2013; 18:296-302. (*contributed equally)

Cario H, McMullin MF, Bento C, Pospisilova D, Percy MJ, Hussein K, Schwarz J, Aström M and Hermouet S. Erythrocytosis in children and adolescents-classification, characterization, and consensus recommendations for the diagnostic approach. Pediatr Blood Cancer. 2013; 60:1734-8.

Hartmann N, Messmann JJ, Leithäuser F, Weiswange M, Kluge M, Fricke H, Debatin K-M and Strauss G. Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions. Blood. 2013; 121:556-65.

Pannicke U, Baumann B, Fuchs S, Henneke P, Rensing-Ehl A, Rizzi M, Janda A, Hese K, Schlesier M, Holzmann K, Borte S, Laux C, Rump E-M, Rosenberg A, Zelinski T, Schrezenmeier H, Wirth T, Ehl S, Schroeder ML and Schwarz K. Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med. 2013; 369:2504-14.

Rassenhofer M, Spröber N, Schneider T and Fegert JM. Listening to victims: use of a Critical Incident Reporting System to enable adult victims of childhood sexual abuse to participate in a political reappraisal process in Germany. Child Abuse Negl. 2013; 37:653-63.

Shlipak MG, Matsushita K, Ärnlöv J, Inker LA, Katz R, Polkinghorne KR, Rothenbacher D, Sarnak MJ, Astor BC, Coresh J, Levey AS and Gansevoort RT; for the CKD Prognosis Consortium. Cystatin C versus creatinine in determining risk based on kidney function. N Engl J Med. 2013; 369:932-43.

Dühren-von Minden M, Übelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Köhler F, Wardemann H, Zirlik K, Veelken H and Jumaa H. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature. 2012; 489:309-12.

Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J and Schrezenmeier H. GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. PloS one. 2012; 7:e43255.

Moss A, Klenk J, Simon K, Thaiss H, Reinehr T and Wabitsch M. Declining prevalence rates for overweight and obesity in German children starting school. Eur J Pediatr. 2012; 171:289-299.

Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RAF, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B and Siebert R; for the ICGC MMML-Seq Project. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet. 2012; 44:1316-20.

Shroff R, Beringer O, Rao K, Hofbauer LC and Schulz A. Denosumab for post-transplantation hypercalcemia in osteopetrosis. N Engl J Med. 2012; 367:1766-7.

Cario H, Smith DEC, Blom H, Blau N, Bode H, Holzmann K, Pannicke U, Hopfner K-P, Rump E-M, Ayric Z, Kohne E, Debatin K-M, Smulders Y and Schwarz K. Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 2011; 88:226-31.

Felgentreff K, Perez-Becker R, Speckmann C, Schwarz K, Kalwak K, Markelj G, Avcin T, Qasim W, Davies EG, Niehues T and Ehl S. Clinical and immunological manifestations of patients with atypical severe combined immunodeficiency. Clin Immunol. 2011; 141:73-82.

Fischer-Posovszky P, Wang QA, Asterholm IW, Rutkowski JM and Scherer PE. Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology. 2011; 152:3074-81.

Meyer LH, Eckhoff SM, Queudeville M, Kraus JM, Giordan M, Stursberg J, Zangrando A, Vendramini E, Möricke A, Zimmermann M, Schrauder A, Lahr G, Holzmann K, Schrappe M, Basso G, Stahnke K, Kestler HA, Te Kronnie G and Debatin K-M. Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell. 2011; 19:206-17.

Schulz AS, Glatting G, Hoenig M, Schuetz C, Gatz SA, Grewendorf S, Sparber-Sauer M, Muche R, Blumstein N, Kropshofer G, Suttorp M, Bunjes D, Debatin K-M, Reske SN and Friedrich W. Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in children with malignant and nonmalignant diseases. Blood. 2011; 117:4642-50.

Gennery AR, Slatter MA, Grandin L, Taupin P, Cant AJ, Veys P, Amrolia PJ, Gaspar HB, Davies EG, Friedrich W, Hoenig M, Notarangelo LD, Mazzolari E, Porta F, Bredius RGM, Lankester AC, Wulffraat NM, Seger R, Güngör T, Fasth A, Sedlacek P, Neven B, Blanche S, Fischer A, Cavazzana-Calvo M and Landais P; for the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation; European Society for Immunodeficiency. Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better? J Allergy Clin Immunol. 2010; 126:602-10.e1-11.

Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David J-P, Reichardt HM, Amling M, Schütz G and Tuckermann JP. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010; 11:517-31.

Nagel G, Wabitsch M, Galm C, Berg S, Brandstetter S, Fritz M, Klenk J, Peter R, Prokopchuk D, Steiner R, Stroth S, Wartha O, Weiland SK and Steinacker J. Determinants of obesity in the Ulm Research on Metabolism, Exercise and Lifestyle in Children (URMEL-ICE). Eur J Pediatr. 2009; 168:1259-67.

Pannicke U*, Hönig M*, Hess I, Friesen C, Holzmann K, Rump E-M, Barth TF, Rojewski MT, Schulz A, Boehm T, Friedrich W and Schwarz K. Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nat Genet. 2009; 41:101-5. (*contributed equally)

Schwarz K, Iolascon A, Verissimo F, Trede NS, Horsley W, Chen W, Paw BH, Hopfner K-P, Holzmann K, Russo R, Esposito MR, Spano D, De Falco L, Heinrich K, Joggerst B, Rojewski MT, Perrotta S, Denecke J, Pannicke U, Delaunay J, Pepperkok R and Heimpel H. Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet. 2009; 41:936-40.

Strauss G, Lindquist JA, Arhel N, Felder E, Karl S, Haas TL, Fulda S, Walczak H, Kirchhoff F and Debatin K-M. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. J Exp Med. 2009; 206:1379-93.

Fischer-Posovszky P, Newell FS, Wabitsch M and Tornqvist HE. Human SGBS cells - a unique tool for studies of human fat cell biology. Obesity facts. 2008; 1:184-189.

Schuetz C, Huck K, Gudowius S, Megahed M, Feyen O, Hubner B, Schneider DT, Manfras B, Pannicke U, Willemze R, Knüchel R, Göbel U, Schulz A, Borkhardt A, Friedrich W, Schwarz K and Niehues T. An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med. 2008; 358:2030-8.

Hönig M, Albert MH, Schulz A, Sparber-Sauer M, Schütz C, Belohradsky B, Güngör T, Rojewski MT, Bode H, Pannicke U, Lippold D, Schwarz K, Debatin K-M, Hershfield MS and Friedrich W. Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications. Blood. 2007; 109:3595-602.

de Quervain DJ-F, Kolassa I-T, Ertl V, Onyut PL, Neuner F, Elbert T and Papassotiropoulos A. A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nat Neurosci. 2007; 10:1137-9.

Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TFE, Bernd H-W, Cogliatti SB, Dierlamm J, Feller AC, Hansmann M-L, Haralambieva E, Harder L, Hasenclever D, Kühn M, Lenze D, Lichter P, Martin-Subero JI, Möller P, Müller-Hermelink H-K, Ott G, Parwaresch RM, Pott C, Rosenwald A, Rosolowski M, Schwaenen C, Stürzenhofecker B, Szczepanowski M, Trautmann H, Wacker H-H, Spang R, Loeffler M, Trümper L, Stein H and Siebert R; for the Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006; 354:2419-30.

Tan JOA and Fegert JM. Capacity and competence in child and adolescent psychiatry. Health Care Anal. 2004; 12:285-94; discussion 265-72.

Fulda S, Wick W, Weller M and Debatin K-M. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med. 2002; 8:808-15.

Schulz AS, Classen CF, Mihatsch WA, Sigl-Kraetzig M, Wiesneth M, Debatin K-M, Friedrich W and Müller SM. HLA-haploidentical blood progenitor cell transplantation in osteopetrosis. Blood. 2002; 99:3458-60.

Friesen C, Herr I, Krammer PH and Debatin K-M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med. 1996; 2:574-7.

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Wünsch M, Schulz AS, Koch W, Friedrich R and Hunsmann G. Sequence analysis of Gardner-Arnstein feline leukaemia virus envelope gene reveals common structural properties of mammalian retroviral envelope genes. EMBO J. 1983; 2:2239-46.