Weidinger lab - publications

Chiara Bongiovanni, Hanna Bueno-Levy, Denise Posadas Pena, Irene Del Bono, Carmen Miano, Stefano Boriati, Silvia Da Pra, Francesca Sacchi, Simone Redaelli, Max Bergen, Donatella Romaniello, Francesca Pontis, Riccardo Tassinari, Laura Kellerer, Ilaria Petraroia, Martina Mazzeschi, Mattia Lauriola, Carlo Ventura, Stephan Heermann, Gilbert Weidinger, Eldad Tzahor and Gabriele D’Uva (2024). BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice. Cell Rep. 43, 114162. doi: 10.1016/j.celrep.2024.114162.

Mirja Harms, Rikke Fabech Hansson, Andrea Gilg, Yasser Almeida-Hernández, Jessica Löffler, Armando Rodríguez-Alfonso, Monica M. W. Habib, Dan Albers, Nermin S. Ahmed, Ashraf H. Abadi, Gordon Winter, Volker Rasche, Ambros J. Beer, Gilbert Weidinger, Nico Preising, Ludger Ständker, Sebastian Wiese, Elsa Sanchez-Garcia, Alexander N. Zelikin, and Jan Münch (2023). Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability. J. Med. Chem. 2023. doi: 10.1021/acs.jmedchem.3c01128

Ivonne Sehring, Hossein Falah Mohammadi, Melanie Haffner-Luntzer, Anita Ignatius, Markus Huber-Lang, and Gilbert Weidinger (2022). Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. elife 11:e77614. doi: 10.7554/eLife.77614.

Alberto Bertozzi, Chi-Chung Wu, Stefan Hans, Michael Brand and Gilbert Weidinger (2022). Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. Dev. Biol. 481, 226–237.

Lara Barthold, Sebastian Heber, Christoph Q. Schmidt, Marion Gradl, Gilbert Weidinger, Holger Barth, and Stephan Fischer (2022). Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding. Int. J. Mol. Sci. 23, 4509. doi: 10.3390/ijms23094509

Ivonne Sehring, and Gilbert Weidinger (2022). The fin roundabout: Slit-Robo and S1P signaling coordinate fin morphogenesis. EMBO Reports e55563. doi: 10.15252/embr.202255563.

Alberto Bertozzi, Chi-Chung Wu, Phong D. Nguyen, Mohankrishna Dalvoy Vasudevarao, Medhanie A. Mulaw, Charlotte D. Koopman, Teun P. de Boer, Jeroen Bakkers, and Gilbert Weidinger (2021). Is zebrafish heart regeneration “complete”? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. Dev. Biol. 471, 106–118. doi: 10.1016/j.ydbio.2020.12.004.

Ivonne Sehring, and Gilbert Weidinger (2021). Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. Cold Spring Harb Perspect Biol. Oct 14:a040758. doi: 10.1101/cshperspect.a040758.

Bastian Beitzinger, Fabian Gerbl, Thomas Vomhof, Roman Schmid, Reiner Noschka, Armando Rodriguez, Gilbert Weidinger, Ludger Ständker, Paul Walther, Jens Michaelis, Mika Lindén, Steffen Stenger (2021). Delivery by Dendritic Mesoporous Silica Nanoparticles Enhances the Antimicrobial Activity of a Napsin-derived Peptide Against Intracellular Mycobacterium tuberculosis. Adv. Healthc. Mater. 10:e2100453. doi: 10.1002/adhm.202100453.

Mirja Harms, Monica M.W. Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H. Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch (2021). An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B, 9:2694-2708. doi: 10.1016/j.apsb.2020.12.005.

Reiner Noschka, Fabian Gerbl, Florian Löffler, Jan Kubis, Armando Rodríguez, Daniel Mayer, Mark Grieshober, Armin Holch, Martina Raasholm, Barbara Spellerberg, Sebastian Wiese, Gilbert Weidinger, Ludger Ständker, Steffen Stenger (2021). Unbiased identification of Angiogenin as an endogenous antimicrobial peptide with activity against virulent Mycobacterium tuberculosis. Front. Microbiol. 11, Article 618278. doi: 10.3389/fmicb.2020.618278.

Reiner Noschka, Fanny Wondany, Gönül Kizilsavas, Tanja Weil, Gilbert Weidinger, Paul Walther, Jens Michaelis, and Steffen Stenger (2021). Gran1: A Granulysin‐Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. Int. J. Mol. Sci. 2021, 22, 8392. doi: 10.3390/ijms22168392.

Rashmi Mishra, Ivonne Sehring, Maria Cederlund, Medhanie Mulaw, and Gilbert Weidinger (2020). NF-κB signaling negatively regulates osteoblast dedifferentiation during zebrafish bone regeneration. Dev. Cell 52, 167–182. doi: 10.1016/j.devcel.2019.11.016.

Ivonne Sehring, and Gilbert Weidinger (2019). Recent advancements in understanding fin regeneration in zebrafish. WIRES Dev Biol. 9: e367. doi: 10.1002/wdev.367.

Hessel Honkoop, Dennis EM de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D Nguyen, Cecilia de Heus, Laurence Garric, Mauro J Muraro, Adam Shoffner, Federico Tessadori, Joshua Craiger Peterson, Wendy Noort, Alberto Bertozzi, Gilbert Weidinger, George Posthuma, Dominic Grun, Willem J van der Laarse, Judith Klumperman, Richard T Jaspers, Kenneth D Poss, Alexander van Oudenaarden, Eldad Tzahor, Jeroen Bakkers (2019). Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLife 8: e50163. doiI: 10.7554/eLife.50163.

Matthias Reisser, Anja Palmer, Achim P. Popp, Christopher Jahn, Gilbert Weidinger & J. Christof M. Gebhardt (2018). Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development. Nat. Comm. 9: 5218. doi: 10.1038/s41467-018-07731.

Yasmine Hachemi, Anna E. Rapp, Ann-Kristin Picke, Gilbert Weidinger, Anita Ignatius, and Jan Tuckermann (2018). Molecular Mechanisms of Glucocorticoids on Skeleton and Regeneration after Fracture. J. Mol. Endocrinol. pii: JME-18-0024.

2017

Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger* and Kerstin Bartscherer* (2017). Generic wound signals initiate regeneration in missing-tissue contexts. Nat. Comm. 8: 2282.
* communicating authors

Daniel Wehner, Themistoklis M. Tsarouchas, Andria Michael, Christa Haase, Gilbert Weidinger, Michell M. Reimer, Thomas Becker, and Catherina G. Becker (2017). Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nat. Comm. 8: 126. DOI: 10.1038/s41467-017-00143-0.

Ajit Magadum, Yishu Ding, Lan He, Teayoun Kim, Mohankrishna Dalvoy Vasudevarao, Qinqiang Long, Kevin Yang, Nadeera Wickramasinghe, Harsha V. Renikunta, Nicole Dubois, Gilbert Weidinger, Qinglin Yang, Felix B. Engel (2017). Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Research doi:10.1038/cr.2017.84.

Erdinc Sezgin, Yagmur Azbazdar, Xue W. Ng, Cathleen Teh, Kai Simons, Gilbert Weidinger, Thorsten Wohland, Christian Eggeling, and Gunes Ozhan (2017). Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. FEBS J. doi: 10.1111/febs.14139.

Gilbert Weidinger (2017). Regeneration: Recorded Live! Curr. Biol. 27, R19–R41.

Christopher Jahn and Gilbert Weidinger (2017). Regulatory T cells know what's needed to regenerate. Dev. Cell 43, 651-652. 

Chi-Chung Wu, Fabian Kruse, Mohankrishna Dalvoy Vasudevarao, Jan Philipp Junker, David C. Zebrowski, Kristin Fischer, Emily S. Noël, Dominic Grün, Eugene Berezikov, Felix B. Engel, Alexander van Oudenaarden, Gilbert Weidinger* and Jeroen Bakkers* (2016). Spatially-resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration. Dev. Cell 36, 36-49.
   * co-senior and co-communicating authors.

Wouter Masselink, Nicholas J. Cole, Fruzsina Fenyes, Silke Berger, Carmen Sonntag, Alasdair Wood, Phong D. Nguyen, Naomi Cohen, Franziska Knopf, Gilbert Weidinger, Thomas E. Hall, Peter D. Currie (2016). A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature 535: 542-546.

Ivonne M. Sehring, Christopher Jahn and Gilbert Weidinger (2016). Zebrafish fin and heart: what’s special about regeneration? Curr Opin Genet Dev 40, 48–56.

Chi-Chung Wu, Gilbert Weidinger (2016). Cardiac Regeneration in Zebrafish. In: Regenerative Medicine-from Protocol to Patient, 3rd edition 2016, p 307-337, Springer International Publishing.

Günes Özhan, Gilbert Weidinger (2015). Wnt/beta-catenin signaling in heart regeneration. Cell Regeneration 4 (1):3, 1-12.

Daniel Wehner, Christopher Jahn, Gilbert Weidinger (2015). Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration. J. Vis. Exp. 100, e52756.

David C. Zebrowski, Silvia Vergarajauregui, Chi-Chung Wu, Tanja Piatkowski, Robert Becker, Marina Leone, Sofia Hirth, Filomena Ricciardi, Nathalie Falk, Andreas Giessl, Steffen Just, Thomas Braun, Gilbert Weidinger, Felix B. Engel (2015). Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. eLife 4:e05563.

Matthew P. Walker, Charles M. Stopford, Maria Cederlund, Fang Fang, Christopher Jahn, Alex D. Rabinowitz, Dennis Goldfarb, David M. Graham, Feng Yan, Allison M. Deal, Yuri Fedoriw, Kristy L. Richards, Ian J. Davis, Gilbert Weidinger, Blossom Damania, and Michael B. Major (2015). FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Sci. Signal. 8, ra12.

Hanna Reuter, Martin März, Matthias C. Vogg, David Eccles, Laura Grífol-Boldú, Daniel Wehner, Suthira Owlarn, Teresa Adell, Gilbert Weidinger, and Kerstin Bartscherer. β-Catenin-Dependent Control of Positional Information along the AP Body Axis in Planarians Involves a Teashirt Family Member. Cell Reports (2015), 10, 253-65.

Daniel Wehner and Gilbert Weidinger (2015). Signaling networks organizing regenerative growth of the zebrafish fin. Trends in Genetics 31, 363-343.

Daniel Wehner, Wiebke Cizelsky, Mohankrishna Dalvoy Vasudevaro, Günes Özhan, Christa Haase, Birgit Kagermeier-Schenk, Alexander Röder, Richard I. Dorsky, Enrico Moro, Francesco Argenton, Michael Kühl and Gilbert Weidinger (2014). Wnt/beta-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin. Cell Reports 6, 467-481.

Karina Geurtzen, Franziska Knopf, Daniel Wehner, Leonie F.A. Huitema, Stefan Schulte-Merker, and Gilbert Weidinger (2014). Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development 141, 2225-2234.

Caghan Kizil, Beate Küchler, Jia-Jiun Yan, Günes Özhan, Enrico Moro, Francesco Argenton, Michael Brand, Gilbert Weidinger and Christopher L. Antos (2014). Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development 141, 3529-3539.

Marta Luz, Stephanie Spannl-Müller, Günes Ozhan, Birgit Kagermeier-Schenk, Muriel Rhinn, Gilbert Weidinger, Michael Brand (2014). Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm. PLoS ONE 9(1):e84922.

Günes Özhan, and Gilbert Weidinger (2014). Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury. In “Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions”. Edited by Stefan P. Hoppler and Randall T. Moon. John Wiley & Sons, Hoboken, New Jersey.

Chi-Chung Wu, and Gilbert Weidinger (2014). Zebrafish as a model for studying cardiac regeneration. Curr. Pathobiol Rep. 2:93–100

Günes Özhan, Erdinc Sezgin, Daniel Wehner, Astrid S. Pfister, Susanne J. Kühl, Birgit Kagermeier-Schenk, Michael Kühl, Petra Schwille, and Gilbert Weidinger (2013). Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev. Cell 26, 331-345.

Bartholomäus Grotek*, Daniel Wehner* and Gilbert Weidinger (2013). Notch signaling coordinates cellular proilferation with differentiation during zebrafish fin regeneration, Development 140, 1412-1423.
* equal contribution

Sebastian Thieme, Tobias Gyárfás, Cornelia Richter, Günes Özhan, Jun Fu, Dimitra Alexopoulou, Michael H. Muders, Irene Michalk, Christiane Jakob, Andreas Dahl, Barbara Klink, Joanna Bandoła, Michael Bachmann, Evelin Schröck, Frank Buchholz, A. Francis Stewart, Gilbert Weidinger, Konstantinos Anastassiadis, and Sebastian Brenner (2013). The histone demethylase UTX regulates stem cell migra-tion and hematopoiesis. Blood 121, 2462-2473.

Enrico Moro, Günes Özhan-Kizil, Alessandro Mongera, Dimitris Beis, Claudia Wierzbicki, Rodrigo M. Young, Despina Bournele, Domenichini Alice, Leonardo E. Valdivia, Lawrence Lum, Chuo Chen , James F. Amatruda, Natascia Tiso, Gilbert Weidinger and Francesco Argenton (2012). In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev. Biol. 15, 327-40.

Donghun Shin, Gilbert Weidinger, Randall T. Moon, Didier Y.R. Stainier (2012). Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mech. Dev. 128, 525-35.

Franziska Knopf, Christina Hammond, Avinash Chekuru, Thomas Kurth, Stefan Hans, Christopher W. Weber, Gina Mahatma, Shannon Fisher, Michael Brand, Stefan Schulte-Merker and Gilbert Weidinger (2011). Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev. Cell 20, 713-724.

Birgit Kagermeier-Schenk, Daniel Wehner, Günes Özhan-Kizil, Hideki Yamamoto, Jian Li, Katharina Kirchner, Christian Hoffmann, Peter Stern, Akira Kikuchi, Alexandra Schambony, Gilbert Weidinger (2011). Waif1/5T4 Inhibits Wnt/β-Catenin Signaling and Activates Noncanonical Wnt Pathways by Modifying LRP6 Subcellular Localization. Dev. Cell 21, 1129-43.

Kristin Schnabel, Chi-Chung Wu, and Gilbert Weidinger (2011). Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLOS One 6, e18503.

Ana Sofia Azevedo, Bartholomäus Grotek, António Jacinto, Gilbert Weidinger* and Leonor Saúde* (2011). The regenerative capacity of the zebrafish caudal fin is not affected by repeated amputations. PLOS One 6: e22820. 
* corresponding authors

Manon C. Verhoeven, Christa Haase, Vincent M. Christoffels, Gilbert Weidinger and Jeroen Bakkers (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth Defects Res. (Part A) 91, 435-40.

Franziska Knopf, Kristin Schnabel, Christa Haase, Katja Pfeifer, Konstantinos Anastassiadis, and Gilbert Weidinger (2010). Dually-inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 107, 19933-19938.

Petros Nemtsas, Erich Wettwer, Torsten Christ, Gilbert Weidinger* and Ursula Ravens* (2010). Adult zebrafish heart as a model for human heart? An electrophysiological study. J. Mol. Cell. Cardiol. 48, 161-171.
* corresponding authors and equal contribution

Wolfram Goessling, Trista E. North, Sabine Loewer, Allegra M. Lord, Sang Lee, Cristi L. Stoick-Cooper, Gilbert Weidinger, Mark Puder, George Q. Daley, Randall T. Moon and Leonard I. Zon (2009). Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration. Cell 136, 1136-47.

Yoonsung Lee, Danyal Hami, Sarah De Val, Birgit Kagermeier-Schenk, Airon A. Wills, Brian L. Black, Gilbert Weidinger and Kenneth D. Poss (2009). Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev. Biol. 331, 270-80.

Jon P. Lyons, Rachel K. Miller, Xiaolan Zhou, Gilbert Weidinger, Tom Deroo, Tinneke Denayer, Jae-Il Park, Hong Ji, Ji Yeon Hong, Annette Li, Randall T. Moon, Elizabeth A. Jones, Kris Vleminckx, Peter D. Vize, Pierre D. McCrea (2009). Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mech. Dev. 126, 142-59.

Elly M. Tanaka and Gilbert Weidinger (2008). Micromanaging regeneration. Genes Dev. 22, 700-705.

Elly M. Tanaka and Gilbert Weidinger (2008). Heads or Tails—Can Wnt tell which one is up? Nat. Cell Biol. 10, 122-124.

Wolfram Goessling, Trista E. North, Allegra M. Lord, Craig Ceol, Sang Lee, Gilbert Weidinger, Caitlin Bourque, Robbert Strijbosch, Anna-Pavlina Haramis, Mark Puder, Hans Clevers, Randall T. Moon and Leonard I. Zon (2008). APC mutant zebrafish uncover a changing temporal requirement for Wnt signaling in liver development. Dev. Biol. 320, 161-74.

Karen A. McFarland, Jolanta M. Topczewska, Gilbert Weidinger, Richard I. Dorsky and Bruce Appel (2008). Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev. Biol. 318, 162-171.

Jennifer Bonner, Suzanna L. Gribble, Eric S Veien, Oliver B. Nikolaus, Gilbert Weidinger and Richard I Dorsky (2008). Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Dev. Biol. 313, 398-407.

Cristi L. Stoick-Cooper, Randall T. Moon, and Gilbert Weidinger (2007). Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev. 21, 1292-1315.

“Gilbert Weidinger: Regeneration researcher”. Interviewed by Ruth Williams (2007). J. Cell Biol. 179, 1088-1089.