med-auz

Publikationen

2023

Li, S., olde Heuvel, F., Rehman, R., Aousji, O., Froehlich, A., Li, Z., Jark, R., Zhang, W., Conquest, A., Woelfle, S., Schoen, M., O´Meara, C. C., Reinhardt, R. L., Voehringer, D., Kassubek, J., Ludolph, A., Huber-Lang, M., Knöll, B., Morganti-Kossmann, M. C., … Roselli, F. (2023). Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. In Nature Communications (Vol. 14, Issue 1). Springer Science and Business Media LLC. doi.org/10.1038/s41467-023-35806-8


Ioannidis, V., Pandey, R., Bauer, H. F., Schön, M., Bockmann, J., Boeckers, T. M., & Lutz, A.-K. (2023). Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium. In Molecular Psychiatry. Springer Science and Business Media LLC. doi.org/10.1038/s41380-023-02362-y


Woelfle, S., Pedro, M. T., Wagner, J., Schön, M., & Boeckers, T. M. (2023). Expression profiles of the autism-related SHANK proteins in the human brain. In BMC Biology (Vol. 21, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s12915-023-01712-0


Jesse, S., Müller, H.-P., Huppertz, H.-J., Andres, S., Ludolph, A. C., Schön, M., Boeckers, T. M., & Kassubek, J. (2023). Neurodegeneration or dysfunction in Phelan-McDermid syndrome? A multimodal approach with CSF and computational MRI. In Orphanet Journal of Rare Diseases (Vol. 18, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s13023-023-02863-7


Pagano, J., Landi, S., Stefanoni, A., Nardi, G., Albanesi, M., Bauer, H. F., Pracucci, E., Schön, M., Ratto, G. M., Boeckers, T. M., Sala, C., & Verpelli, C. (2023). Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling. In Molecular Autism (Vol. 14, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s13229-023-00557-2


Aousji, O., Feldengut, S., Antonucci, S., Schön, M., Boeckers, T. M., Matschke, J., Mawrin, C., Ludolph, A. C., Del Tredici, K., Roselli, F., & Braak, H. (2023). Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. In Acta Neuropathologica Communications (Vol. 11, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s40478-023-01616-8


Olde Heuvel, F., Ouali Alami, N., Aousji, O., Pogatzki-Zahn, E., Zahn, P. K., Wilhelm, H., Deshpande, D., Khatamsaz, E., Catanese, A., Woelfle, S., Schön, M., Jain, S., Grabrucker, S., Ludolph, A. C., Verpelli, C., Michaelis, J., Boeckers, T. M., & Roselli, F. (2023). Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model. In Molecular Autism (Vol. 14, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s13229-023-00552-7


Woelfle, S., Deshpande, D., Feldengut, S., Braak, H., Del Tredici, K., Roselli, F., Deisseroth, K., Michaelis, J., Boeckers, T. M., & Schön, M. (2023). CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. In BMC Biology (Vol. 21, Issue 1). Springer Science and Business Media LLC. doi.org/10.1186/s12915-023-01582-6

Bauer, H. F., Delling, J. P., Bockmann, J., Boeckers, T. M., & Schön, M. (2023). Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders. In Frontiers in Behavioral Neuroscience (Vol. 16). Frontiers Media SA. doi.org/10.3389/fnbeh.2022.1051175

Schön, M., Lapunzina, P., Nevado, J., Mattina, T., Gunnarsson, C., Hadzsiev, K., Verpelli, C., Bourgeron, T., Jesse, S., van Ravenswaaij-Arts, C. M. A., & Hennekam, R. C. (2023). Definition and clinical variability of SHANK3-related Phelan-McDermid syndrome. In European Journal of Medical Genetics (Vol. 66, Issue 7, p. 104754). Elsevier BV. doi.org/10.1016/j.ejmg.2023.104754

Vitrac, A., Leblond, C. S., Rolland, T., Cliquet, F., Mathieu, A., Maruani, A., Delorme, R., Schön, M., Grabrucker, A. M., van Ravenswaaij-Arts, C., Phelan, K., Tabet, A.-C., & Bourgeron, T. (2023). Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome. In European Journal of Medical Genetics (Vol. 66, Issue 5, p. 104732). Elsevier BV. doi.org/10.1016/j.ejmg.2023.104732

Messerer, D. A. C., Behr, J. L., Kraft, S. F., Schön, M., Horneffer, A., Kühl, S. J., Benedikt Seifert, L., Huber‐Lang, M., Böckers, T. M., & Böckers, A. (2023). The gross anatomy course:<scp>SARS‐CoV</scp>‐2 pandemic‐related effects on students’ learning, interest in peer‐teaching, and students’ perception of its importance. In Anatomical Sciences Education (Vol. 16, Issue 4, pp. 629–643). Wiley. doi.org/10.1002/ase.2245

Publikationen bis 2021

(in alphabetical order)

[1] M. H. Arons, C. J. Thynne, A. M. Grabrucker, D. Li, M. Schoen, J. E. Cheyne, T. M. Boeckers, J. M.
Montgomery, and C. C. Garner, “Autism-Associated Mutations in ProSAP2 / Shank3 Impair
Synaptic Transmission and Neurexin – Neuroligin-Mediated Transsynaptic Signaling”, J Neurosci,
2012.

[2] D. M. Cochoy, A. Kolevzon, Y. Kajiwara, M. Schoen, M. Pascual-Lucas, S. Lurie, J. D. Buxbaum, T. M.
Boeckers, and M. J. Schmeisser, “Phenotypic and functional analysis of SHANK3 stop mutations
identified in individuals with ASD and/or ID”, Mol. Autism, 2015.

[3] S. Cursano, C. R. Battaglia, C. Urrutia-Ruiz, S. Grabrucker, M. Schön, J. Bockmann, S. Braumüller , P. Radermacher, F. Roselli, M. Huber-Lang, T.M. Boeckers, “A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome”, Mol. Psychiatry, 2020.

[4] Y. C. Dai, H. F. Zhang, M. Schön, T. M. Böckers, S. P. Han, J. S. Han, R. Zhang, “Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism”, Front. Cell. Neurosci., 2018.

[5] A. Dolnik, N. Kanwal, S. Mackert, S. Halbedl, C. Proepper, J. Bockmann, M. Schoen, T. M. Boeckers,
S. J. Kühl, and M. J. Schmeisser, “Sipa1l3/SPAR3 is targeted to postsynaptic specializations and
interacts with the Fezzin ProSAPiP1/Lzts3”, J. Neurochem., 2016.

[6] S. Grabrucker, J. C. Haderspeck, A. K. Sauer, N. Kittelberger, H. Asoglu, A. Abaei, V. Rasche, M. Schön, T. M. Boeckers, A. M. Grabrucker, “Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder”, Front. Mol. Neurosci., 2018.

[7] S. Grabrucker, J. Pagano, J. Schweizer, C. Urrutia-Ruiz, M. Schön, K. Thome, G. Ehret, A. M. Grabrucker, R. Zhang, B. Hengerer, J. Bockmann, C. Verpelli, C. Sala, T. M. Boeckers, “Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism“, EMBO J., 2021.

[8] A. M. Grabrucker*, M. J. Schmeisser*, M. Schoen*, and T. M. Boeckers, “Postsynaptic ProSAP/Shank
scaffolds in the cross-hair of synaptopathies”, Trends Cell Biol., 2011.
* these authors contributed equally to this work

[9] A. M. Grabrucker, M. J. Schmeisser, P. T. Udvardi, M. Arons, M. Schoen, N. S. Woodling, K. I. Andreasson, P. R. Hof, J. D. Buxbaum, C. C. Garner, and T. M. Boeckers, “Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold”, Mol. Neurodegener., 2011.

[10] S. Halbedl, M. Schoen, M. S. Feiler, T. M. Boeckers, and M. J. Schmeisser, “Shank3 is localized in
axons and presynaptic specializations of developing hippocampal neurons and involved in the
modulation of NMDA receptor levels at axon terminals”, J. Neurochem., 2016.

[11] C. Heise, J. C. Schroeder, M. Schoen, S. Halbedl, D. Reim, S. Woelfle, M. R. Kreutz, M. J. Schmeisser,
and T. M. Boeckers, “Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in
the Mouse Hippocampus”, Front. Cell. Neurosci., 2016.

[12] J. Iaconisi, F. Hasselblatt, B. Mayer, M. Schoen, T.M. Böckers, A. Böckers, “Effects of an Educational Film About Body Donors on Students' Empathy and Anxiety Levels in Gross Anatomy.”, Anat. Sci. Educ., 2019.

[13] S. Jesse, J.P. Delling, M. Schön, T.M. Boeckers, A. Ludolph, M. Senel, “Phelan McDermid Syndrome: Multiple Sclerosis as a Rare but Treatable Cause for Regression-A Case Report”, Int. J. Mol. Sci., 2021.

[14] S. Liebau, C. Proepper, T. Schmidt, M. Schoen, J. Bockmann, and T. M. Boeckers, “ProSAPiP2, a
novel postsynaptic density protein that interacts with ProSAP2/Shank3”, Biochem. Biophys. Res.
Commun., 2009.

[15] S. Liebau, J. Steinestel, L. Linta, A. Kleger, A. Storch, M. Schoen, K. Steinestel, C. Proepper, J.
Bockmann, M. J. Schmeisser, and T. M. Boeckers, “An SK3 channel/nWASP/Abi-1 complex is
involved in early neurogenesis”, PLoS One, 2011.

[16] A. K. Lutz, S. Pfaender, B. Incearap, V. Ioannidis, I. Ottonelli, K. J. Föhr, J. Cammerer, M. Zoller, J. Higelin, F. Giona, M. Stetter, N. Stoecker, N. O. Alami, M. Schön, M. Orth, S. Liebau, G. Barbi, A. M. Grabrucker, R. Delorme, M. Fauler, B. Mayer , S. Jesse, F. Roselli, A. C. Ludolph, T. Bourgeron, C. Verpelli, M. Demestre, T. M. Boeckers, “Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles.” Sci. Transl. Med., 2020.

[17] M. G. Mameza, E. Dvoretskova, M. Bamann, H. H. Hönck, T. Güler, T. M. Boeckers, M. Schoen, C.
Verpelli, C. Sala, I. Barsukov, A. Dityatev, and H. J. Kreienkamp, “SHANK3 gene mutations
associated with autism facilitate ligand binding to the SHANK3 ankyrin repeat region”, J. Biol.
Chem., 2013.

[18] S. Peykov, S. Berkel, M. Schoen, K. Weiss, F. Degenhardt, J. Strohmaier, B. Weiss, C. Proepper, G.
Schratt, M. M. Nöthen, T. M. Boeckers, M. Rietschel, and G. A. Rappold, “Identification and
functional characterization of rare SHANK2 variants in schizophrenia”, Mol. Psychiatry, 2015.

[19] C. Prelli Bozzo, R. Nchioua, M. Volcic, J. Krüger, S. Heller, C.M. Stürzel, D. Kmiec, C. Conzelmann, J. Müller, F. Zech, D. Schütz, L. Koepke, E. Braun, R. Groß, L. Wettstein, T. Weil, J. Weiß, D. Sauter, J. Münch, F. Diofano, C. Goffinet, A. Catanese, M. Schön, T. Böckers, S. Stenger, K. Sato, S. Just, A. Kleger, K. M. J. Sparrer, F. Kirchhoff, “IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition”, Nat. Comm., 2020.

[20] M. J. Schmeisser, S. J. Kühl, M. Schoen, N. H. Beth, T. M. Weis, A. M. Grabrucker, M. Kühl, and T. M.
Boeckers, “The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in
developing neurons”, Neural Dev., 2013.

[21] M. Schoen*, H. Asoglu*, H. F. Bauer, H.-P. Müller, A. Abaei, A. K. Sauer, R. Zhang, T.-J. Song, J. Bockmann, J. Kassubek, V. Rasche, A. M. Grabrucker, T. M. Boeckers, “Shank3 Transgenic and Prenatal Zinc-Deficient Autism Mouse Models Show Convergent and Individual Alterations of Brain Structures in MRI”, Front. Neural Circuits, 2019.
* these authors contributed equally to this work

[22] M. Schön, C. Lindenau, A. Böckers, C.-M. Altrock, L. Krys, A. Nosanova, N. Lang, A. Renz, J. Kroschel, E. Pensel, C. Grab, B. Mayer, D. A. C. Messerer, U. Fassnacht, J. P. Delling, M. Engelmann, A. Horneffer, M. Zernickel, K.-M. Debatin, J. Münch, F. Kirchhoff, T. Wirth, T. M. Boeckers, “Longitudinal SARS-CoV-2 infection study at Ulm University“, medRxiv, 2021.

[23] M. Schön, A. Nosanova, C. Jacob, J.M. Kraus, H.A.K. Kestler, B. Mayer, S. Feldengut, K. Amunts, K. Del Tredici, T. M. Boeckers,  H. Braak, “A comparative study of pre-alpha islands in the entorhinal cortex from selected primates and in lissencephaly“, J. Comp. Neurol., 2021.

[24] M. Schoen, J. M. Reichel, M. Demestre, S. Putz, D. Deshpande, C. Proepper, S. Liebau, M. J.
Schmeisser, A. C. Ludolph, J. Michaelis, and T. M. Boeckers, “Super-Resolution Microscopy Reveals
Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons”, Front. Cell.
Neurosci., 2016.

[25] M. Schön*, K. Steinestel*, D. Spiegelburg, A. Risch, M. Seidel, L. Schurr, U. K. Fassnacht, N. Golenhofen, T. M. Böckers, A. Böckers. “Integration of Scientific Competence into Gross Anatomy Teaching Using Poster Presentations: Feasibility and Perception among Medical Students“, Anat. Sci. Educ., 2020.
* these authors contributed equally to this work

[26] T. J. Song, X. Y. Lan, M. P. Wei, F. J. Zhai, T. M. Boeckers, J. N. Wang, S. Yuan, M. Y. Jin, Y. F. Xie, W. W. Dang, C. Zhang, M. Schön, P. W. Song, M. H. Qiu, Y. Y. Song, S. P. Han, J. S. Han, R. Zhang, “Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion” Front. Cell. Neurosci., 2019.

[27] C. Verpelli, E. Dvoretskova, C. Vicidomini, F. Rossi, M. Chiappalone, M. Schoen, B. Di Stefano, R.
Mantegazza, V. Broccoli, T. M. Böckers, A. Dityatev, and C. Sala, “Importance of Shank3 protein in
regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses”, J.
Biol. Chem., 2011.