Previous Talks

Prof. Anne-Sophie Hafner

Department of Molecular Neurobiology, Donders Centre for Neuroscience, Radboud University Nijmegen, NL

Date: 30.01.2023, 3 pm
Location: Centre of Quantum BioScience, ZQB, M26, Room No. 2202, Ground Floor

Brief description

Anne-Sophie Hafner and her team study the dynamic composition of synapses, the molecular basis of memory encoding in the brain. Anne-Sophie Hafner is most known for unravelling the first presynaptic transcriptome from mature excitatory boutons in the forebrain and demonstrating the abundance of active protein synthesis in all synaptic compartments: postsynapses as well as excitatory and inhibitory presynaptic boutons. Her lab uses omics-approaches combined with FACs-based synapse purification, metabolic labelling, super-resolution, and live-imaging to elucidate changes in synapse composition associated with learning, aging and diseases. The Hafner lab aims for a better understanding of synaptic function in health and disease, to help the development of innovative preventive and therapeutic approaches to brain dysfunction.

Everybody welcome!

Host: Prof. Dr. Birgit Liss
birgit.liss@uni-ulm.de

Mitochondria – endoplasmic reticulum crosstalk as therapeutic target against aging, cancer and diabetes

Univ.-Prof. Mag. pharm. Dr. rer. nat. Wolfgang F. Graier

Chair of Gottfried Schatz Research Center, Head of Division Molecular Biology and Biochemistry, Medical University of Graz

Date: 15.12.2022, 4 pm
Duration: 40-45 min
Location: N27, Room 4.053 (glassbox)

Brief description

Mitochondria are not only the master of cellular energy metabolism, but they are also involved in multiple vital processes, including signal transduction, biosynthesis, and gene expression. Mitochondria are crucially involved in most pathological processes leading to cell dysfunctions and, ultimately, cell death. The reason for such ubiquitous involvement of mitochondria in cellular physiology and pathology is mainly achieved by the intense interaction of the organelle with virtually all other cellular compartments. Accordingly, the endoplasmic reticulum (ER) – mitochondria axis received enormous attention. This interorganelle interface is organized in so-called, mitochondria-associated membranes (MAMs), the site where the exchange of substrates, products, and ions occurs. Particularly the latter one, namely Ca2+, appears to be a fundamental regulator of such inter-organellar communication. Recent studies revealed abnormal inter-organellar Ca2+ transfer as a hallmark in many diseases like Alzheimer, diabetes mellitus, cancer, and aging. Applying state-of-the-art techniques such as super-resolution fluorescence microscopy (pmid: 3577844231427612 ), single Ca2+ channels recordings in the inner mitochondrial membrane (pmid: 26275882 23397170), structure biology techniques like NMR or ITC (pmid: 27642082 ), and the design of genetically encoded biosensors (pmid: 2684290729127288, 31636543; www.ngfi.eu), we discovered posttranslational arginine methylation of the primary regulator of the mitochondrial Ca2+ uptake, MICU1 (pmid: 3577844227642082) that engages UCP2 as a crucial facilitator for mitochondrial Ca2+ uptake (pmid: 17351641) under distinct pathological conditions. Accordingly, we are now able to envisage the role of the ER-mitochondria axis for  (re-)wiring (pmid: 35058562), e.g. as the instigator of ß-cell dysfunction has been identified. Hence specific alterations in the ER-mitochondria axis have been identified in aging and cancer (pmid: 3045832133614647). Based on this work, we are currently successfully testing potential leading compounds uniquely designed to counteract cell aging- or cancer-specific settings at the ER-mitochondria interface. Our latest findings reveal an excellent specificity of these compounds that exclusively hits senescent or cancer cells and highlight the great potential of such strategies and compounds against aging-associated dysfunction and cancer growth. 

Everybody welcome!

Host: Prof. Dr. Birgit Liss
Tel.: +49 731 500-36200
birgit.liss@uni-ulm.de

 

UCL Queen Square Institute of Neurology, London (UK)

Titel: "Gene therapy for refractory epilepsy."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Invitation

Spanish National Biotechnology Centre (CNB), Madrid

Titel: "Development of new modulators of the KChip3 / DREAM interactome."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Einladung

 

IOCB Prague, Institute for Biochemistry and Molecular Biology

Titel: "Trafficking of T-type calcium channels in health and desease."

Location: Building N27, Multimedia room 2nd floor

Chair: Liss

Invitation

DZNE Research Team Experimental Neurophysiology

Titel: "Critical Developmental Periods in Ion Channelopathie."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Einladung

Swiss Federal Institute of Technology / ETH Zürich
Department of Health Sciences and Technology

https://www.hest.ethz.ch/das-departement/personen0/professuren/persdetail.html?persid=228841

Titel: "Behavioural orchestration by brain orexin circuits"

Time: 5:00 pm

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

<link file:338218 download file>Einladung

National Institute of Neurological Disorders and Stroke, Division of Intramural Research Cellular Neurophysiology Unit, Bethesda MD (USA)

https://neuroscience.nih.gov/ninds/Faculty/Profile/zayd-khaliq1.aspx

 "Exitability and Integration in SNc Dopamine Neuron Subpopulations."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Einladung

Institute for Stroke and Dementia Research (ISD) / Klinikum der Universität München

www.klinikum.uni-muenchen.de/Institut-fuer-Schlaganfall-und-Demenzforschung/de/kontakt/mitarbeiter/gokce/index.html

"Beyond the D1/D2 receptor dichotomy in basal ganglia circuits."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Einladung

Basal Ganglia Pathophysiology, Lund University, Sweden.

http://portal.research.lu.se/portal/en/persons/angela-cenci-nilsson(a87e3de5-6f9c-4670-bc84-c83f8f7183b1).html

 "Striatal output pathways in Parkinson's disease and L-DOPA-inducted dyskinesia"

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Invitation Flyer

Department of Neuroscience, Physiology and Pharmacology University College London (UCL), UK.

https://www.ucl.ac.uk/biosciences/departments/npp

"Neuronal calcium channel trafficking and function: relevance to chronic pain."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).
Chair: Liss

Invitation Flyer.

Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford, UK.

https://www.dpag.ox.ac.uk/team/dayne-beccano-kelly 

"Possible interplay of synuclein, activity and calcium homeostasis in iPSC derived dopamine neurons."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

Invitation Flyer

Institute for Pharmacology, Medical University Innsbruck, Austria.

https://www.i-med.ac.at/pharmakologie/index.html.de 

Prof. Ferraguti will give the main talk for Session II, Neurobiology, at the IGradU Fall Meeting 2017.

"Specialized amygdala inhibitory networks for emotional learning."

Chair: Liss.

Inivitation.

Department of Cell and Developmental Biology, University College London.

https://www.ucl.ac.uk/biosciences/departments/cdb/people/sandip-patel/sandip-patel-lab

"Non canonical signalling through acidic Ca2+ stores."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).
Chair: Liss

Invitation.

College of Biological Sciences, Department of Pharmacology, University of California, Davis, USA.

Webpage

"Regulation of the L-type Ca channel Cav1.2 and its function in synaptic plasticity."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).
Chair: Liss

Invitation Flyer

Guest Professor, IGradU Molecular Medicine:

http://www.uni-ulm.de/einrichtungen/mm/news-details/article/visit-of-our-new-guest-professor-ying-zhang-from-dalhousie-university-halifax-canada/

Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

https://medicine.dal.ca/departments/department-sites/medical-neuroscience/our-people/our-faculty/ying-zhang.html

Students lecture, IGradU:

“The organization of spinal locomotor circuits and motorneuron diseases.” 

Room: Building N27, Multimedia Room 2.059

Chair: Liss

Invitation

Guest Professor, IGradU Molecular Medicine:

http://www.uni-ulm.de/einrichtungen/mm/news-details/article/visit-of-our-new-guest-professor-ying-zhang-from-dalhousie-university-halifax-canada/

Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

https://medicine.dal.ca/departments/department-sites/medical-neuroscience/our-people/our-faculty/ying-zhang.html

The spinal interneurons that enable us to run.” 

Room: Building N27, Multimedia Room 2.059

Chair: Liss

Invitation

Ludwig-Maximilians-Universität, Munich, Germany

"Exploring the connection between metabolism and epigenetic during aging and cognitive impairment."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

> Invitation Flyer.

Departments of Pharmacology and Neurosciences, CNS Research group
Faculty of Medicine, University of Montréal, Canada

http://www.mapageweb.umontreal.ca/trudeal/english/indexA.html

"Axonal arborization and energetic metabolism of nigral dopamine neurons:
 a window into selective vulnerability in Parkinson's disease."

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

> Invitation Flyer.

Neuroscience, Cell Biology, Molecular Biology Erasmus University Rotterdam, Netherlands

www.erasmus.nl

"Cross-talk between genomic instability, metabolism and redox homeostatsis in Parkinson Disease"

Location: Building N27, Room 4.053 (glass seminar room AG Liss).

Chair: Liss

> Invitation Flyer.

Department of Medical Neurobiology, Institute of Medical Research Israel-Canada,
The Faculty of Medicine, The Hebrew University of Jerusalem

http://www.medicine.ekmd.huji.ac.il

"Alpha-synuclein overexpression induces stressless pacemaking
  in vagal motoneurons at risk in Parkinson's disease"

Location: Building N27, Room 4.053 (glas seminar room AG Liss).

Chair: Liss

Director of the Multi-agency Thematic Institute (ITMO), Neuroscience, Paris, France.

http://www.aviesan.fr/en

"Unmet therapeutic needs for Parkinson disease"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Faculty of Life Science, University of Manchester, UK.

http://www.ls.manchester.ac.uk/people/profile/?alias=pigginsh

"Clocks, Arousal, and Exercise"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Hertie-Institute, Department of Neurodegenerative Disease, DZNE, University of Tübingen

https://www.dzne.de/en/sites/tuebingen.html

"Investigating the link between GBA1 mutations and Parkinson's disease with stem cell model systems"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Head Ion channels and Diseases Lab, Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic

http://theweisslab.com/what-we-do/

"T-type calcium channels: from molecular trafficking to vesicular exocytosis"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Department of Neuroscience, University of Pittsburgh, USA

http://www.pitt.edu/~graceaa/

"The Circuitry of Dopamine System Regulation and it´s Disruption in Schizophrenia and Depression"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Institute of Pharmacy, Eberhard Karls University Tuebingen

http://www.uni-tuebingen.de/en/faculties/faculty-of-science/departments

"The Ca2+ activated K+ channels BK and SK4 control Ca2+ entry in a cell type specific manner"

Location: Building N27, Room 4.053 (glass seminar room AG Liss)

Chair: Liss

Northwestern University Feinberg, School of Medicine, Chicago, USA. 

http://labs.feinberg.northwestern.edu/opal/members/index.html

"The role of Calcium and Mitochondrial Bioenergetics in the Vulnerability of Midbrain Dopaminergic Neurons"

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

University of Edinburgh, Centre for Integrative Physiology, Scottland. 

http://www.ed.ac.uk/schools-departments/integrative-physiology

"Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output"

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Universitätsmedizin Göttingen, Department of Neurology. 

http://www.neurologie.med.uni-goettingen.de/index_en.html

"Neurotrophins for disease modification in Parkinson disease - there is still hope?"

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Department of General Zoologie and Neurobiology, Ruhr University Bochum.

http://www.ruhr-uni-bochum.de/neurobiol/index.html.de

"Control of 5HT signals and anxiety by light activated GPCRs."

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

TATAA Biocenter, Department of Gene Expression, University of Prague, Czech Republic.

http://genexp.ibt.cas.cz/

"Single Cell Expression Profiling - New Insights into complex biology."

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Department of Physiology & Pharmacology, Medical University of Calgary, Canada.

http://www.hbi.ucalgary.ca/members/zamponi

"Voltage gated calcium channels as targets for pain therapeutics."

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Guest Professor, IGradU Molecular Medicine:

Department of Biochemistry & Molecular Biology, University of Chicago.

http://memprotein.org/about-the-consortium/team-members/eduardo-perozo

Students lecture, IGradU:

Basic Principles Underlying Ion Channel Function: A Biochemical and Structural Perspective.” 

Room: Multimedia Room 2.059

Chair: Liss

Guest Professor, IGradU Molecular Medicine:

Department of Biochemistry & Molecular Biology, University of Chicago.

http://memprotein.org/about-the-consortium/team-members/eduardo-perozo

Structural Basis of Voltage-Sensing in Ion channels and Enzymes.” 

Room: N25, H8

Chair: Liss

Institute of Physiological Chemistry, Department of Molecular Cell Biology, Ruhr University Bochum.

http://www.ruhr-uni-bochum.de/physiolchem/zellbio/index.html.de

“Parkin: a stress-protective E3 ubiquitin ligase associated with Parkinson's disease.”

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Dalhouse University, Canada.

http://medical-neuroscience.medicine.dal.ca/zhang/

“Can we walk, can we walk well? The story of V3 interneurons in the spinal cord.”

Room: N27, Raum 4.053 (glass seminar room AG Liss)

Chair: Liss

Institute of Physiology, University of Rostock.

http://physiologie.med.uni-rostock.de/staff/koe/koe.htm

“Alterations of the AHP in a chronic temporal lobe epilepsy model.”

Room: N27, Raum 4.052 (Seminarraum AG Liss)

Chair: Liss

Institute of Physiology, University of Freiburg.

http://www.bioss.uni-freiburg.de/cms/fakler.html

“Native AMPA receptors in the mammalian brain - insight from high-resolution proteomics.”

Room: Life Science Building, N27, 2nd floor, Seminar Room AG Liss, No 4.053.

Chair: Liss

Laboratory of Pharmacology and GIGA Neurosciences, University of Liège, Belgium.

http://www.giga.ulg.ac.be/jcms/prod_198038/vincent-seutin

“Midbrain dopaminergic neurons: from mechanisms of pacemaking to in vivo effects of drugs of abuse”

Room: Life Science Building, N27, 2nd floor, Seminar Room AG Liss, No 4.053.

Chair: Liss