Molecular psychotraumatology

Research topics

04/2009−03/2014 DFG Emmy Noether Junior Research Group within the DFG Research Unit Science of Social Stress on the topic of stress- and trauma-associated immunological changes and their effects on health.
01/2013−12/2016 BMBF project: Stress resilience in the transgenerational transmission of childhood maltreatment. J. Fegert (coordinator), H. Gündel, I.-T. Kolassa
01/2019−12/2022 BMBF project: Enhancing understanding and treatment of post-traumatic stress disorder related to child maltreatment (ENHANCE; coordinator: F. Leichsenring), subproject I.-T. Kolassa: Preventing premature morbidity and mortality after childhood maltreatment: Reversing the molecular toxicity of traumatic stress through trauma-focused therapies.

Boeck, C., Gumpp, A.M., Calzia, E., Radermacher, P., Waller, C., Karabatsiakis, A., Kolassa, I.-T. (2018). The association between cortisol, oxytocin and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment. Psychoneuroendocrinology, 96, 69-77.

Boeck, C., Salinas-Manrique, J., Calzia, E., Radermacher, P., von Arnim, C. A. F., Detlef, D., Kolassa, I.-T., Karabatsiakis, A. (2018). Targeting the association between telomere length and immune-cellular bioenergetics in female patients with major depressive disorder. Scientific Reports, e9419.

Geiger, M. L., Boeck, C., Koenig, A. M., Schury, K., Waller, C., Kolassa, S., Karabatsiakis, A., Kolassa, I.-T. (2018). Investigating the effects of child maltreatment experiences on inflammation: The influence of cortisol and DHEA on cytokine secretion ex vivo. Mental Health and Prevention. Early online.

Koenig, A., Alexandra M., Ramo-Fernández, L., Boeck, C., Umlauft, M., Pauly, M., Binder, E.B., Kirschbaum, C., Gündel, H., Karabatsiakis, A., Kolassa, I.-T. (2018). Intergenerational gene × environment interaction of FKBP5 and childhood maltreatment on hair steroids. Psychoneuroendocrinology, 92, 103-112.

Koenig, A. M., Reister, F., Gao, W., Umlauft, M., Schury, K., Kirschbaum, K., Karabatsiakis, A., Kolassa, I.-T. (2018). Altered hair endocannabinoid levels in mothers with childhood maltreatment and their newborns. Biological Psychology, 35, 93-101.

Boeck, C., Pfister, S., Bürkle, A., Vanhooren, V., Libert, C., Salinas-Manrique, J., Dietrich, D. E., Kolassa, I.-T., Karabatsiakis, A. (2018). Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder. Journal of Affective Disorders, 234, 139-147.

Koenig, A.M., Karabatsiakis, A., Stoll, T., Wilker, S., Hennessy, T., Hill, M. M., & Kolassa, I.-T. (2018). Serum profile changes in individuals with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study. Scientific Reports, 8:e3468.

Boeck, C., Krause, S., Karabatsiakis, A., Schury, K., Gündel, H., Waller, C., Kolassa, I.-T. (2017). History of child maltreatment and telomere length in immune cell subsets: Associations with stress and attachment-related hormones. Development and Psychopathology. Epub ahead of print.

Boeck, C., Koenig, A. M., Schury, K., Geiger, M. L., Karabatsiakis, A., Wilker, S., Waller, C., Gündel, H., Fegert, J. M., Calzia, E., Kolassa, I.-T. (2016). Inflammation in adult women with a history of child maltreatment: the involvement of mitochondrial alterations and oxidative stress. Mitochondrion, 30, 197-207.

Wilker, S., Pfeiffer, A., Elbert, T. Ovuga, E., Karabatsiakis, A., Krumbholz, A., Thieme, D., Schelling, G., Kolassa, I.-T. (2016). Endocannabinoid Concentrations in Hair are Associated with PTSD Symptom Severity. Psychoneuroendocrinology, 67:198-206.

Karabatsiakis, A., Hamuni, G., Wilker, S., Kolassa, S., Renu, D., Kadereit, S., Schauer, M., Hennessy, T. & Kolassa, I.-T. (2015). Metabolite profiling in posttraumatic stress disorder. Journal of Molecular Psychiatry, 3(1):e2.

Karabatsiakis, A., Kolassa, I.-T., Kolassa, S., Rudolph, K.-L., Dietrich, D. E. (2014). Telomere shortening in leukocyte subpopulations in depression. BMC Psychiatry, 14(1): e192.

Wilker, S., Elbert, T., Papassotiropoulos, A., de Quervain, D. J.-F., Kolassa, I.-T. (2014). Response to: further support for an association between the memory-related gene WWC1 and posttraumatic stress disorder: results from the Detroit Neighborhood Health Study. Biological Psychiatry, 76(11), 27-28.

Karabatsiakis, A., Böck, C., Manrique, J.S., Kolassa, S., Calzia, E., Dietrich, D.E., Kolassa, I.-T. (2014). Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Translational Psychiatry, 4, e397.

Morath, J., Moreno-Villanueva, M., Hamuni, G., Kolassa, S., Ruf, M., Schauer, M., Bürkle, A., Elbert, T., Kolassa, I.-T. (2014). Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress. Psychotherapy and Psychosomatics, 83(5), 289-297.