Publications

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons
Daniel Sommer, Sandeep Rajkumar, Kerstin Mira Schneider-Seidel, Amr Aly, Albert C. Ludolph, Ritchie
Ho, Tobias M. Boeckers and Alberto Catanese,
Front Mol Neurosci., 2022 June

Epigenetic clocks for mice based on age-associated regions that are conserved between mouse strains and human
Juan Perez-Correa, Vithurithra Tharmapalan, Hartmut Geiger and Wolfgang Wagner , Front Cell Dev
Biol., 2022 June

CANTATA-prediction of missing links in Boolean networks using genetic programming
Christoph Müssel, Nensi Ikonomi, Silke D Werle, Felix M Weidner, Markus Maucher, Julian D Schwab, Hans A Kestler
Bioinformatics, 2022 October

 

Epigenetic biomarkers to track differentiation of pluripotent stem cells
Schmidt M, Zeevaert K, Elsafi Mabrouk MH, Goetzke R, Wagner W
Stem Cell Reports, 2023 January

YAP1 is essential for self-organized differentiation of pluripotent stem cells
Zeevaert K, Goetzke R, Elsafi Mabrouk MH, Schmidt M, Maaßen C, Henneke A-C, He C, Gillner A, Zenke M, Wagner W
Biomater. Adv., 2023 March

Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis
Alberto Catanese, Sandeep Rajkumar , Daniel Sommer , Pegah Masrori, Nicole Hersmus, Philip Van
Damme , Simon Witzel, Albert Ludolph , Ritchie Ho, Tobias M Boeckers, Medhanie Mulaw,
Brain., 2023 March

Leveraging quantum computing for dynamic analyses of logical networks in systems biology
Felix M Weidner, Julian D Schwab, Sabine Wölk, Felix Rupprecht, Nensi Ikonomi, Silke D Werle, Steve Hoffmann, Michael Kühl, Hans A Kestler
Patterns (N Y), 2023 March

TFIIH mutations can impact on translational fidelity of the ribosome
Fatima Khalid , Tamara Phan, Mingyue Qiang, Pallab Maity, Theresa Lasser, Sebastian Wiese, Marianna Penzo, Marius Alupei,
Donata Orioli, Karin Scharffetter-Kochanek and Sebastian Iben,
Hum Mol Genet., 2023 March

Epigenetic rejuvenation by partial reprogramming
Puri D, Wagner W.
Bioessays, 2023 April

Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance
Giorgio Caratti, Ulrich Stifel, Bozhena Caratti, Ali J M Jamil, Kyoung-Jin Chung, Michael
Kiehntopf, Markus H Gräler, Matthias Blüher, Alexander Rauch, Jan P Tuckermann,
Nat Commun., 2023 April

To aggregate or not to aggregate - Is it a matter of the ribosome?
Sebastian Iben
Bioessays., 2023 May

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
Sabrina F Mansilla, Agostina P Bertolin , Sofía Venerus Arbilla, Bryan A Castaño, Tiya Jahjah, Jenny K
Singh , Sebastián O Siri, María Victoria Castro, María Belén de la Vega, Annabel Quinet , Lisa Wiesmüller, Vanesa Gottifredi
Sci Adv., 2023 June

Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis
Bocova L, Hubens W, Engel C, Koschmieder S, Jost E, Wagner W
Clin. Epigenetics, 2023 June

Myelofibrosis at diagnosis is associated with the failure of treatment-free remission in CML patients
Jacobi H, Vieri M, Bütow M, Namasu CY, Flüter L, Costa IG, Maié T, Lindemann-Docter K, Chatain N, Beier F, Huber M, Wagner W, Crysandt M, Brümmendorf TH, Schemionek M.
Front. Pharmacol., 2023 July

Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients
Volkan Yazar, Julia K Kühlwein, Antje Knehr, Veselin Grozdanov, Arif B Ekici , Albert C Ludolph, Karin M Danzer,
Sci Rep., 2023 July

Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy.
Zhu G, Khalid F, Zhang D, Cao Z, Maity P, Kestler HA, Orioli D, Scharffetter-Kochanek K, Iben S.,
Cells., 2023 July

The weakness of senescent dermal fibroblasts
Lydia Rebehn, Samira Khalaji, Fenneke KleinJan, Anja Kleemann, Fabian Port, Patrick Paul, Constantin Huster, Ulla Nolte, Karmveer Singh, Lisa Kwapich, Jonas Pfeil, Taner Pula, Pamela Fischer-Posovszky, Karin Scharffetter-Kochanek, Kay-E Gottschalk
Proc Natl Acad Sci U S A, 2023 August

Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome
Salz L, Seitz A, Schäfer D, Franzen J, Holzer T, Garcia-Prieto CA, Bürger I, Hardt O, Esteller M, Wagner W
Leukemia, 2023 September

Simulating space conditions evokes different DNA damage responses in immature and mature cells of the human Hematopoietic system
Leonie Handwerk, Heike Katrin Schreier, Daniela Kraft, Kateryna Shreder, Ruth Hemmersbach , Jens
Hauslage , Halvard Bonig, Lisa Wiesmüller , Claudia Fournier, Melanie Rall-Scharpf,
Int. J Mol Sci., 2023 September

Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice
Dominik Pflumm, Alina Seidel, Fabrice Klein, Rüdiger Groß, Lea Krutzke, Stefan Kochanek , Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck
Front. Immunol., 2023 September

A protocol for the use of cloud-based quantum computers for logical network analysis of biological systems
Felix M Weidner, Mirko Rossini, Joachim Ankerhold, Hans A Kestler
STAR Protoc., 2023 September

Cellular aging is accelerated in the malignant clone of myeloproliferative neoplasms
Vieri M, Tharmapalan V, Kalmer M, Baumeister J, Nicolic M, Schnitker M, Kirschner M, Flosdorf N, de Toledo M A S, Zenke M, Koschmieder S, Brümmendorf T H, Beier F, Wagner W
Blood Cancer, 2023 November

The skin of the naked mole-rat and its resilience against aging and cancer
Meinhard Wlaschek , Karmveer Singh, Pallab Maity, Karin Scharffetter-Kochanek,
Mech Aeging Dev., 2023 November

CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs
Puri D, Maaßen C, Varona Baranda M, Zeevaert K, Hahnfeld L, Hauser A, Fornero G, Elsafi Mabrouk MH, Wagner W
Front Cell Dev Biol., 2023 November

 

GatekeepR: an R Shiny application for the identification of nodes with high dynamic impact in Boolean networks
Felix M Weidner, Nensi Ikonomi, Silke D Werle, Julian D Schwab , Hans A Kestler
Bioinformatics, 2024 January

Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche
Flosdorf N, Böhnke J, de Toledo MAS, Lutterbach N, Gómez Lerma V, Grasshoff M, Olschok K, Gupta S, Tharmapalan V, Schmitz S, Götz K, Schüler HM, Maurer A, Sontag S, Küstermann C, Sere K, Wagner W, Costa IG, Brümmendorf TH, Koschmieder S, Chatain N, Castilho M, Schneider RK, Zenke 
Stem Cell Reports, 2024 February

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids
Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Brenda Krishnacoumar, R Verena Taudte , Charlotte Grund , Gitta Erdmann, Carina Scholtysek, Stefan Uderhardt, Oumaima Ben Brahim , Mónica Pascual Maté , Cornelia Stoll , Martin Böttcher , Katrin Palumbo-Zerr, Matthew S J Mangan, Maria Dzamukova , Markus Kieler, Melanie Hofmann, Stephan Blüml, Gernot Schabbauer, Dimitrios Mougiakakos , Uwe Sonnewald , Fabian Hartmann, David Simon , Arnd Kleyer  , Anika Grüneboom, Susetta Finotto, Eicke Latz, Jörg Hofmann, Georg Schett , Jan Tuckermann , Gerhard Krönke,
Nature., 2024 April

Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons
Johannes Lehmann , Amr Aly , Christina Steffke , Luca Fabbio, Valentin Mayer,  Natalie Dikwella, Kareen Halablab, Francesco Roselli, Simone Seiffert, Tobias M Boeckers , David Brenner, Edor Kabash , Medhanie Mulaw, Ritchie Ho, Alberto Catanese,
Cell Death Dis., 2024 August

Overexpression of Toxic Poly(Glycine-Alanine) Aggregates in Primary Neuronal Cultures Induces Time-Dependent Autophagic and Synaptic Alterations but Subtle Activity Impairments
Christina Steffke, Shreya Agarwal, Edor Kabashi, Alberto Catanese
Cells., 2024 August

Guidelines for minimal information on cellular senescence experimentation in vivo
Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D Adams, Fabrizio d'Adda di Fagagna, Darren J Baker, Cleo L Bishop , Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber , Eiji Hara, Pidder Jansen-Dürr, Diana Jurk , Sundeep Khosla, James L Kirkland, Valery Krizhanovsk , Tohru Minamino, Laura J Niedernhofer , João F Passos, Nadja A R Ring, Heinz Redl, Paul D Robbins, Francis Rodier, Karin Scharffetter-Kochanek, John M Sedivy, Ewa Sikora , Kenneth Witwer, Thomas von Zglinicki , Maximina H Yun, Johannes Grillari, Marco Demaria,
Cell., 2024 August

Biomarkers for aging of blood – how transferable are they between mice and humans?
Tharmapalan V, Wagner W.
Exp Hematol., 2024 August

Substrate elasticity does not impact DNA methylation changes during differentiation of pluripotent stem cells
Elsafi Mabrouk M. H., Zeevaert K., Henneke A.-C., Maaßen C., Wagner W. 
Cytotherapy, 2024 September

Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging
Shiyun Long , Yunchao Zheng, Xiaoling Deng, Jing Guo, Zhe Xu, Karin Scharffetter-Kochanek , Yanmei Dou , Min Jiang
Commun Bio., 2024 October

Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment
Sachin Kumar, Jeffrey D Vassallo, Kalpana J Nattamai, Aishlin Hassan, Angelika Vollmer, Rebekah Karns, Mehmet Sacma, Travis Nemkov, Angelo D'Alessandro, Hartmut Geiger
Aging Cell, 2024 October

Three-year changes in high-sensitivity cardiac troponin-T and total mortality in older adults
Dhayana Dallmeier, Johanna Braisch, Michael Denkinger, Wolfgang Koenig, Dietrich Rothenbacher 
Sci. Rep, 2024 November

Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer
Schmidt M, Maié T, Cramer T, Costa IG, Wagner W. 
Clin Epigenetics, 2024 November

Quantitative determination of the spatial distribution of components in single cells with CellDetail
Tanja Schuster,  Amanda Amoah, Angelika Vollmer , Gina Marka, Julian Niemann , Mehmet Saçma , Vadim Sakk, Karin Soller, Mona Vogel, Ani Grigoryan , Meinhard Wlaschek, Karin Scharffetter-Kochanek, Medhanie Mulaw, Hartmut Geiger
Nat. Commun, 2024 November

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia
Lia-Raluca Olari, Sichen Liu, Franziska Arnold, Julia Kühlwein, Marta Gil Miró, Ajeet Rijal Updahaya, Christina Stürzel, Dietmar Rudolf Thal, Paul Walther, Konstantin M J Sparrer, Karin M Danzer, Jan Münch, Frank Kirchhoff
Nat. Commun., 2025 January