| Project | Title | Principal Investigator |
|---|---|---|
| Project Group A | Experimental leukemia models | |
| A1 | The contribution of mechanisms of aging of HSCs to leukemia initiation and progression | H. Geiger |
| A3 | Notch signaling as a novel target of AML1/ETO | F. Oswald H. Geiger |
| A4 | Dissecting of the function of the “Lymphoid enhancer-binding factor 1” (Lef1) in acute myeloid leukemia | C. Buske |
| A6 | The role of homeobox genes in erythroid leukemia | M. Feuring-Buske |
| A9 | Role of B cell receptor signaling and acquired immunoglobulin gene changes in the development of chronic lymphocytic leukemia (CLL) | E. Hobeika H. Jumaa |
| A10 | Investigating the crosstalk between pre-BCR and IL7-R signaling in B-cell precursor acute lymphoblastic leukemia | H. Jumaa |
| Project Group B | Clinical translations | |
| B1 | Genomic instability, disease evolution and rational treatment development in CLL mouse models | A. Müller S. Stilgenbauer |
| B2 | Mechanisms of CLL progression and Richter transformation in patients with CLL treated with agents targeting BTK and BCL2 | D. Mertens |
| B3 | Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation | K. Döhner L. Bullinger |
| B6 | Multi-targeting and identification of synergistic activities to overcome therapy resistance in ALL | L.-H. Meyer K.-M. Debatin |
| B8 | The role of deubiquitinating enzyme USP7 in the pathogenesis and treatment of acute myeloid leukemia | J. Krönke |
| B9 | Causes and consequences of the epigenetic disturbances in T-pro-lymphocytic leukemia | L. Wiehle R. Siebert |
| B10 (new) | Genetic and epigenetic charaterization of chronic lymphocytic leukemia with translocations involving the immunoglobulin loci | A. Mottok R. Siebert |
| B11 (new) | Novel oncogenes in complex karyotype acute lyeloid leukemia | C. Plass |
| B12 (new) | Disscting AML treatment response to FLT3 inhibitors by single-cell sequencing | K. Rippe K. Döhner |
| Central Projects | ||
| Z1 | Bioinformatics core: semantic knowledge fusion and non-standard optimization Single-cell sequencing core | H. Kestler K. Rippe |
| Z2 | Central Project Management | H. Döhner |
| Z3 | The core unit mass spectrometry and proteomics | S. Wiese |