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1998
 
Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.
  1 M H Siegel DRK Dresden auto 1:2 *
before 1997
 weak D type 2 RHD(G385A)
6 7

  2 N I Eicher SRK Bern (CH) allo 1:128
before 1997
 DNB RHD(G355S)
2 3

  3 C B Lonicer BRK München allo 1:32
1997
 DNB RHD(G355S)
2 3

  4 Z-y Zhu Shanghai (China) allo 1:128
not reported
 DVI type III RHD-Ce(3-6)-D (exon scanning)
4

  5 C Lonicer BRK München allo 1:1
before 1997
 weak D type 15 RHD(G282D)
6 7

  6 N I Eicher SRK Bern (CH) auto 1:1 *
1987
 weak D type 1 RHD(V270G)
6 7

  7 D Schönitzer Blutbank Innsbruck (A) allo 1:16
1993
 DNB RHD(G355S)
2 3

  8 C Gassner Blutbank Innsbruck (A) allo 1:32
before 1997
 DNB RHD(G355S)
2 3

  9 S Kilga-Nogler Blutbank Innsbruck (A) allo 1:16
1960s
 DIIIc RHD-CE(3)-Dc 1
10 E Rainer Blutbank Innsbruck (A) auto 1:8 *
before 1997
 regular D  RHD hemizygous (RHD deletion PCR-RFLP)
1

11 T H Müller DRK Oldenburg auto 1:4 *
before 1997
 weak D type 2 RHD(G385A)
6 7

12 N I Eicher SRK Bern (CH) allo 1:16
before 1998
 DIII type IV RHD (L62F,A137V,N152T)
6

13 C Green BTS Edinburgh (Scotland) allo 1:64
not reported
 D cat Va (Hus.) RHD-CE(5)-D
1 5

14 B Ladewig Biotest AG Dreieich allo 1:128
before 1997
 weak D type 4.2.2 RHD(T201R,F223V,I342T)
6 8

15 B Ladewig Biotest AG Dreieich auto 1:1 *
before 1997
 weak D type 4.2.1 RHD(T201R,F223V,I342T)
6 8

16 M Palfi Uni Linköpping (S) & Lund (S) allo 1:32
before 1997
 DFL
 RHD(Y165C)
2

1999
 
Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.
17 E Becker Uni Magdeburg auto 1:2 *
1995
 regular D CDe/CDe: RHD + RHD(IVS5-38del4)
2

18 I von Zabern DRK Gera allo 1:4
before 1997
 DIV type IV RHD-CE(7:D350H-A354N)-D
2 13

19 C Green BTS Edinburgh (Scotland) allo 1:64
not reported
 DVI type 2 RHD-Ce(4-6)-D (exon scanning)
1

20 J Perkins Hospital Blood Bank, Evanston IL (USA) allo 1:8
1971
 DVI type 2 RHD-Ce(4-6)-D (exon scanning)
1

21 A Salama Charite, Berlin auto 1:64 *
1999
 weak D type 1 RHD(V270G)
1

22 M Geurts Blood Service - Waikato, Hamilton (NZ) auto 1:32 *
1998
 weak D type 1 RHD(V270G)
1

23 N I Eicher SRK Bern (CH) allo 1:1
before 1997
 DIV type III RHD-CE(6-9)-D
9

24 N I Eicher SRK Bern (CH) allo 1:256
before 1997
 DIV pending

2000

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.
25 N I Eicher SRK Bern (CH) allo <1:1
before 1994
 DVII RHD(L110P)
1

26 W A Flegel DRK Ulm allo 1:2
before 1997
 DIV type III RHD-CE(6-9)-D
9

27 B Ladewig Biotest AG Dreieich allo 1:128
1992
 DOL/Cde S RHD(M170T,F223V) , CdeS
2 10

28 B Zimmermann DRK Bremen allo 1:8
July 1999
 DVI type II RHD-Ce(4-6)-D (exon scanning)
1

29 A Seltsam Charite Berlin allo 1:256
April 2000
 DIV type IV RHD-CE(7:D350H-A354N)-D 1 13
30 A Agildere Uni Regensburg auto <1:1 *
Dec 1999
 weak D type 2 RHD(G385A)
1

31 S Wegener DRK Rostock auto 1:1 *
papain only
June 2000
 weak D type 1 RHD(V270G)
1

32 M Kerowgan DRK Mannheim auto 1:1 *
1996
 weak D type 1 RHD(V270G)
1

33 B Ekermo Uni Linköpping (S) auto 1:1 *
1999
 weak D type 1 RHD(V270G)
1

34 E K Petershofen DRK Frankfurt allo 1:2
March 2000
 DVII RHD(L110P)
12

35 D Teixidor DRK Frankfurt allo 1:2
not reported
 DVII RHD(L110P)
1

36 E K Petershofen DRK Frankfurt allo titer not reported
1952
 R 0Har RHCE-D(5)-CE
11

37 E M Quenzel DRK Hagen allo 1:32
March 2000
 R 0Har RHCE-D(5)-CE
1

38 K Angert Uni Aachen allo 1:1
1992
 DAU-3
 RHD(V279M,T379M)
2

2001

Entry Serologist Institute anti-D immunized Trivial name RHD work-up
Ref.
39 E M Quenzel DRK Hagen auto 1:128
Sep 2000
 weak D type 1 RHD(V270G)
1

40 W A Flegel DRK Ulm auto 1:4 Jan 2001 weak D type 2 RHD(G385A) 1
41 J Jorgensen Uni Aarhus (DK) allo 1:4
not reported
 DNB RHD(G355S)
2 3

42 N I Eicher SRK Bern (CH) allo/auto 1:1
before 1997
 weak D type 4.0.1
 RHD(T201R,F223V)
1

43
 N I Eicher
 SRK Bern (CH) allo 1:8
since 1997
 DIIIc
 RHD-CE(3)-D
1

44
 R Zimmermann
 Uni Erlangen
Juli 2000
pending

45
 S Frandson
 San Diego Blood Bank (USA)
 allo 1:16
not reported
 DIIIc
 RHD-CE(3)-D
1

46
 E M Quenzel
 DRK Hagen
 auto 1:32
in 2000
 weak D type 2
 RHD(G385A)
1

2002

Entry
 Serologist
 Institute
 anti-D
 immunized
 Trivial name
 RHD work-up
Ref.
47
 E M Quenzel
 DRK Hagen
 allo 1:256
before 1997
 R0Har
 RHCE-D(5)-CE
1

48 H P Geisen
 Diakonie Schwäbisch Hall
 auto 1:4
Nov 2001
 weak D type 1
 RHD(V270G)
1

49
 E M Quenzel
 DRK Hagen
 allo 1:8
Nov 2001
 DNB
 RHD(G355S)
2 3

50
 N I Eicher
 SRK Bern (CH)
 allo 1:1
Nov 2001
 DVII
 RHD(L110P)
1

51
 N I Eicher
 SRK Bern (CH)
 allo/auto titer unknown
unknown
 weak D type 4.0.0/RHDPsi
 RHD(T201R,F223V) , RHDPsi

52
 M R Combs
 Duke Durham NC (USA)
 auto 1:32
Jan 2002
weak D type 2
 RHD(G385A)
1

53
 E M Quenzel
 DRK Hagen
 allo 1:1000 + auto
Dec 2001
R 0Har
 RHCE-D(5)-CE
1


54
 M R Combs
 Duke Durham NC (USA)
 allo 1:8
Sept 1997
 DVI type II
 RHD-Ce(4-6)-D (exon scanning)
1

55
 M R Combs
 Duke Durham NC (USA)
 allo 1:1
Oct 2001
DAU-4
 RHD(E233K,T379M)
1

56
 H Velhagen
 DRK Berlin
 allo 1:1
before 1997
 DHMi
 RHD(T283I)
1

57
 A Opitz
 Uni Würzburg
 auto 1:8
before 1997
 regular D
 RHD homozygous (RHD deletion PCR-RFLP)
1

58
 H P Geisen
 Diakonie Schwäbisch Hall
 allo 1:4
before 1997
 DVI type 2
 RHD-Ce(4-6)-D (exon scanning)
1

59
 J Poole
 IBGRL Bristol (England)
 auto 1:1
in 2001
 weak D type 1
 RHD(V270G)
1

60
 F F Wagner
 DRK Ulm
 auto 1:4
in 2001
 weak D type 1
 RHD(V270G)
1

61
 A Himmel
 DRK Bad Kreuznach
 auto 1:1
2000 or 2001
 weak D type 1
 RHD(V270G)
1

62
 W Antl
 Klinikum Nürnberg
 auto 1:8
 Juni 2002
 weak D type 33
 RHD(V174M)
 1
63
 K Wenz
 DRK Kassel
 auto 1:8
before 1997
 weak D type 2
 RHD(G385A)
1

64
 N I Eicher
 SRK Bern (CH)
 allo 1:256
1997
 weak D type 11
 RHD(M295I) in CDe haplotype
1

65
 M R Combs
 Duke Durham NC (USA)
 auto 1:128
Feb 2002
 DIII type V
 RHD(L62F,A127V,N152T,T201R,F223V)
1

66
 C Gabriel
 Blutzentrale Linz (A)
 1:1
Sept 1999
DVI type I
 RHD-cE(4-5)-D (exon scanning)
1

2003

Entry
 Serologist
 Institute
 anti-D
 immunized
 Trivial name
 RHD work-up
Ref.
67
 S Glinz
 Pistoia (I)
 auto 1:8
before 1997
 regular D 
 RHD hemizygous (RHD deletion PCR-RFLP)
1

68
 C Lonicer
 BRK München
 allo <1:1
before 1997
 R0Har
 RHCE-D(5)-CE
1

69
 A Himmel
 DRK Bad Kreuznach
 allo 1:2
1960
 DVI type I
 RHD-cE(4-5)-D (exon scanning)
1

70
 M Heuberger
 DRK Kassel
 auto 1:2
after 1999
 weak D type 1
 RHD(V270G)
1

71
 A Habibi
 DRK Kassel
 allo 1:32
before 1997
 DVI type III
 RHD-Ce(3-6)-D (exon scanning)
1

72
 W Antl
 Klinikum Nürnberg
 allo 1:4
unknown
 DVI type I
 RHD-cE(4-5)-D (exon scanning)
1

73
 I von Zabern
 DRK Bad Kreuznach
 auto 1:4
May 2003
weak D type 1
 RHD(V270G)
1

74
 H Hustinx
 SRK Bern (CH)
 allo 1:4+auto
after 1999
 DVII
 RHD(L110P)
1

75
 C Gabriel
 Blutzentrale Linz (A)
 auto 1:1
unknown
 regular D
 RHD homozygous (RHD deletion PCR-RFLP)
1

76
 P Pavel
 Uni Halle
 auto 1:512
after 1998
 regular D
 RHD homozygous (RHD deletion PCR-RFLP)
1

77
 E Strobel
 Städt. Krankenhaus München-Schwabing
 allo 1:4
June 2002
 R0Har
 RHCE-D(5)-CE
1

78
 W. Röhrl
 Städt. Krankenhaus München-Perlach
 allo 1:32000
Sept 2003
 DVI type II
 RHD-Ce(4-6)-D (exon scanning)
1

79
 J Lüdecke
 BRK Nürnberg
 auto <1:1
Dec 2002
 weak D type 1
 RHD(V270G)
1

80
 M Heuberger
 DRK Kassel
 allo 1:1
before 1997
 DIV type IV
 RHD-CE(7:D350H-A354N)-D
13

81
 M R Combs
 Duke Durham NC (USA)
 auto 1:8
Nov 2003
 regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
2004

Entry
 Serologist
 Institute
 anti-D
 immunized
 Trivial name
 RHD work-up
Ref.
82
 U Prockat
 DRK-Kliniken Berlin
 1:4
before 1997
 DDE
 RHD(D40E) 2
83
 R Kempf
 BG-Kliniken Bochum
 auto 1:1
Jan 2004
 regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
84
 E Holzberg
 Gemeinschaftspraxis Weiden
 allo 1:16
in 2001
pending

85
 W Endres
 Katharinenhospital Stuttgart
 allo 1:128
before 1997
 DIV type IV
 RHD-CE(7:D350H-A354N)-D
13

86
 C Gabriel Blutzentrale Linz (A) allo 1:1
 Aug 1998
 DVI type II RHD-Ce(4-6)-D (exon scanning) 1
87
 A Seltsam
 Uni Hannover
 allo 1:2
 before 1997 DIVb
 RHD-CE(7-9)-D 1
88
 F Etzel
 Praxisgemeinschaft Bonn
 allo 1:16
 in 2003
 R 0Har RHCE-D(5)-CE 1
89
 W A Flegel
 IKT Ulm
 allo 1:8
 before 1997 DNB RHD(G355S) 1
90
 B Just
 DRK West Hagen
 allo 1:1
 Jan 2002
 DNB
 RHD(G355S) 1
91
 E M Quenzel Kliniken Schwerin
 auto 1:2
 unknown regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
92
 N Grunnet
 Uni Aarhus (DK) auto 1:32
 July 2004
 weak D type 5
 RHD(A149D) 1
93
 T Weiland
 Medilys Blutdepot Hamburg
 allo/auto titer 1:1
 after 1997
 weak D type 4.0.0/RHDPsi 
 RHD(T201R,F223V) , RHDPsi










2005

Entry Serologist Institute anti-D immunized Trivial name RHD work-up Ref.
94
 A Mildner
 Klinikum Reutlingen
 allo 1:8
 1996
 DIV type III RHD-CE(6-9)-D 9
95
 E M Quenzel Kliniken Schwerin auto 1:2
 unknown
 weak D type 3/regular D
 RHD(S3C), RHD; homozygous (RHD deletion PCR-RFLP)
 1
96
 A Habibi
 DRK Kassel auto 1:2
 May 2005
 weak D type 1
 RHD(V270G) 1
97
 B Just
 DRK West Hagen allo 1:32
 Oct 2002
 R 0Har RHCE-D(5)-CE 1









2006

Entry Serologist Institute anti-D immunized Trivial name RHD work-up Ref.
98
 I Menke-Möllers
 Wisplinghoff & Kollegen Köln
 allo 1:4
 Dec 2005
 R 0Har RHCE-D(5)-CE 1
99
 Quibell P
 Prince George BC (CDN)
 auto 1:2
 Apr 2005
 weak D type 2 RHD(G385A) 1
100
 I von Zabern IKT Ulm anti-LWa 1:2 1999
 DFV (without anti-D)
 RHD(F223V) aka D667; LWa negative
 2
101
 H Hustinx SRK Bern (CH) allo 1:64
 1998
 DV type 7
 RHD-CE(5:F223V-G263R)-D

102
 I von Zabern IKT Ulm auto 1:2 Nov 2004
 weak D type 1 RHD(V270G) 1
103
 H Hustinx SRK Bern (CH) allo/auto titer 1:1 2003
 weak D type 4.2.2/RHDPsi RHD(T201R,F223V,I342T) , RHDPsi    


104
 H Hustinx SRK Bern (CH) allo <1:1
 July 2006
 DNB RHD(G355S) 1
105
 B Just DRK West Hagen allo 1:8 June 2006
 DIV type IV RHD-CE(7:D350H-A354N)-D 13









2007
106
 B Just DRK West Hagen allo 1:2 unknown R 0Har RHCE-D(5)-CE 1
107
 M Waldner
 Ospedala S. Chiara, Trento (I)
 auto 1:4
 March 2006
 weak D type 1 RHD(V270G) 1
108
 P Pavel
 Uni Halle-Wittenberg
 auto 1:4
 before 1997 regular D RHD hemizygous (RHD deletion PCR-RFLP) 1
109
 W A Flegel
 IKT Ulm auto 1:16
 Oct 2007
 weak D type 1 RHD(V270G) 1
110
 K P Strathmann
 DRK West Breitscheid, Ratingen
 allo 1:4
 March 2007
 DMI RHD(M170I)










2008
111
 S Enkel
 ZKT Tübingen
 allo/auto 1:32
 2007
 DNU
 RHD(G353R) in CDe haplotype 1
112
 M K Moulds
 LifeShare Shreveport (USA)
 allo 1:16
 unknown partial D pending 1
113
 K P Strathmann DRK West Breitscheid, Ratingen allo/auto 1:4
 Jan 2008 DVII
 RHD(L110P) 1
114
 A Stenzel
 DRK West Breitscheid, Ratingen allo 1:16
 2006 R 0Har RHCE-D(5)-CE 1
115
 G Denomme
 Toronto ON (CDN)
 auto 1:4
 Dec 2007
 weak D type 1 RHD(V270G) 1
116
 M Heuberger
 DRK Kassel auto 1:128
 Nov 2007
 weak D type 2 RHD(G385A) 1
117
 K P Strathmann DRK West Breitscheid, Ratingen auto 1:4 May 2008
 regular D CDe/cde: RHD(IVS5-38del4) + RHD deletion 2
118
 J Burkhart
 BRK München
 allo 1:16
 2006
 DIVa-2

RHD(L62F, N152T, D350H)
1
119
 P Pirzer
 Klinikum St. Marien, Amberg
 allo 1:8
 Mar 1988
 DIV type 5 RHD-CE(7-9)-D
1
120
 J-M Minon
 C.H.R. de la Citadelle, Liege (B)
 allo 1:64
2008
 weak D type 4.2.3/RHDPsi RHD(T201R,F223V,I342T) , RHDPsi 1
121
 K P Strathmann DRK West Breitscheid, Ratingen auto 1:1
 Oct 2008 weak D type 2 RHD(G385A) 1
122
 A-M Hittmann
 DRK West Breitscheid, Ratingen allo/auto 1:1
 July 2008 weak D type 4.2 subtype & serology pending
 1
123
 G Denomme Toronto ON (CDN) auto 1:2
 Sept 2008
 weak D type 1 RHD(V270G) 1









2009
124
 H-D Barth
 DRK NSTOB Gera
 auto 1:4
 Juli 2008
 weak D type 33
 RHD(V174M) 1





































foreign laboratory



published by the consortium


Gerne untersuchen wir Ihre Proben Anmeldung zur Untersuchung: Voraussetzungen
Versandbogen (deutsch)






Your entries are welcome How to submit samples? 
It's easy!
Report form (English)





References
  • 1. No plans to publish.  
  • 2. Manuscipt in preparation or published: Click on RHD allele for link to reference.
  • 3. Wagner, F.F., Gassner, C., Eicher, N.I., Lonicer, C.B., Flegel, W.A.: Characterization of D category IV type IV, DFW, and DNB (abstract). Transfusion 38;1998:63S and Wagner, F.F., Eicher, N.I., Jorgensen J.R., Lonicer, C.B., Flegel, W.A.: DNB: a partial D with anti-D frequent in Central Europe. Blood 100:2002:2253
  • 4. Flegel, W.A., Wagner, F.F., Müller, T.H., Gassner, C.: Rh phenotype prediction by DNA typing and its application to practice. Transfus Med 8;1998:281 View full text online  
  • 5. The RHD allele D cat Va (Hus.) was originally described in: Rouillac, C., Colin, Y., Hughes-Jones, N.C., Beolet, M., D'Ambrosio, A.-M., Cartron, J.-P., Le Van Kim, C.: Transcript analysis of D category phenotypes predicts hybrid Rh D-CE-D proteins associated with alteration of D epitopes. Blood 85;1995:2937-2944  
  • 6. Wagner, F.F., Frohmajer, A., Ladewig, B., Eicher, N.I., Lonicer, C.B., Müller, T.H., Siegel, M.H., Flegel, W.A.: Weak D alleles express distinct phenotypes. Blood 95;2000:2699-2708  
  • 7. Wagner, F.F., Gassner, C., Müller, T.H., Schönitzer, D., Schunter, F., Flegel, W.A.: Molecular basis of weak D phenotypes. Blood 93;1999:385 View full text online
  • 8. Weak D type 4.2.1 and type 4.2.2 resemble the partial D DAR but carry one and two, respectively, additional silent mutations. DAR was described in: Hemker MB, Ligthart PC, Berger L, van Rhenen DJ, van der Schoot CE, Maaskant-van Wijk PA: DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks. Blood 94;1999:4337-4342  
  • 9. The RHD allele D cat IV type III was originally described in reference 6 (immunohematology) and reference 7 (molecular biology).
  • 10. Avent, N.D., Poole, J., Singleton, B., Chabert, T., Romeiras, M.C., Rodrigues, M.J., Watt, J., Bruce, H.: Studies of two partial Ds: DMH and DOL. Transfus. Med. 9(suppl) 33, 1999 (Abstract) 
  • 11. Petershofen, E.K., Teixidor, D., Rabold, U., Heuberger, G., Sireis, W., Seifried, E.: Alloanti-D antibody production in a Rh33 R O HAR patient. A case report. Vox Sang. 78(supp 1) P033, 2000 (Abstract) 
  • 12. Petershofen, E.K., Teixidor, D., Doescher, A., Rabold, U., Hundhausen, T., Spika, A., Schmidt-Matilla, E.W., Schunter, F., Seifried, E.: Induction of alloanti-D antibodies after transfsuion of RBC in a patient with Rhesus-D category VII. Transfus. Clin. Biol. 8(suupl 1) 172s (P421), 2001 (Abstract) 
    • 13. Wagner, F.F., Gassner, C., Eicher, N.I., Lonicer, C., Flegel, W.A.: Characterization of D category IV type IV, DFW, and DNB. Transfusion 38:63S, 1998. (Abstract)




     

     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     

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  • * Evaluation of the case reports revealed positive antibody elution with or without auto-antibodies in serum.
    		•

    all titers in LISS/antiglobulin/gel technique; n.d. - not determined   

     


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